Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-09-04
2007-09-04
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S406000, C544S124000, C548S365700
Reexamination Certificate
active
11025373
ABSTRACT:
The present invention provides compounds having formula (I):and pharmaceutically acceptable derivatives thereof, wherein R1, R2and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
REFERENCES:
patent: 5997868 (1999-12-01), Goldberg et al.
patent: 6432406 (2002-08-01), Goldberg et al.
patent: 6589997 (2003-07-01), Pillarisetti et al.
patent: 6610726 (2003-08-01), Pillarisetti et al.
patent: 2003/0022924 (2003-01-01), Pillarisetti et al.
patent: 2003/0045559 (2003-03-01), Pillarisetti et al.
patent: 2003/0216459 (2003-11-01), Pillarisetti et al.
patent: 2005/0113369 (2005-05-01), Zembower et al.
patent: 138 770 (1979-11-01), None
patent: 48 000713 (1973-01-01), None
patent: 02-193994 (1990-07-01), None
patent: 11-288112 (1999-10-01), None
patent: WO 01/02369 (2001-01-01), None
patent: WO0134650 (2001-05-01), None
patent: WO 200134650 (2001-05-01), None
patent: WO 02/02593 (2002-01-01), None
patent: WO 02/02593 (2002-01-01), None
patent: WO 200202593 (2002-01-01), None
patent: WO 2004/009599 (2004-01-01), None
Rahmoune et al. “Hepatocyte growth factor/scatter factor has distinct classes of binding site in heparan sulfate from mammary cells,” Biochemistry, vol. 37, pp. 6003-6008 (1998).
Anzaldi, et al., “Synthesis and antimicrobial activity of heterocyclic ionone-like derivatives”,Eur. J. Med. Chem., 34: 837-842, 1999.
Invitation to Pay Additional Fees for related application No. PCT/US2003/040917.
Attaby et al., “Reactions with Cyanothioacetamide and its Derivatives: Synthesis and Reactions of Several New Thieno- and Azolopyridine Derivatives”Phosphorus, Sulfur, Silicon and the Related Elements, 119, 1-10, 1996.
Boekelheide et al., “Syntheses of Fused Aromatic Heterocycles by 1,3-Dipolar Addition Reactions. 3-Azapyrrocolines”Journal of Organic Chemistry, 33(5), 2062-4, 1968.
Eldin et al., “Reactions with Cyanothioacetamide Derivatives: Systhesis and Reactions of Some Pyridine and Annelated Pyridine Derivatives”Egypt. J Pharm Sci, 34(4-6), 805-815, 1993.
Elghandour et al., “A Facile Synthesis of Pyrazolo [1,5-a]pyridine Derivatives: Reaction of Cinnamonitriles with 5-Amino-4-cyano-3-cyanomethlypyrazole”J. Prakt. Chem., 330(4), 657-660, 1988.
Rateb, Iet al., “Reactions of Hydroxymethylene Ketones. Part II, Other Routes for the Preparation of Isoxazoles and Pyrazoles”Journal of the Chemical Society(C), 17, 2137-9, 1968.
Schneider, et al., “Facile Synthesis of Cyclopropyl Alkadienes”Angewandte Chemie, 91(3), 231-234, 1979.
Schvartsberg, et al., “Acetylenic Derivatives of Heterocycles. Transformations of 3-ethynylpyrazole”Khimiya Geterotsiklicheskikh Soedinenii, 4(4), 695-697, 1968.
Sottofatori, et al., “Synthesis of New Heterocyclic Derivatives of Retinoids”Journal of Heterocyclic Chemistry, 35(6), 1377-1380, 1998.
Subramaniam, et al., “Nonlinear Optic Properties of Heterocyclic Compounds Hyperpolarizability-structure Correlation”Ferroelectrics and Related Materials, 122(1-4), 229-38, 1991.
Tsuruta, et al., “Isolation of a Potential Intermediate Leading to 9-Phenylbicyclo[4.2.1]nona-2,4,7-triene in the Thermal Decomposition of α-Phenyl-α-tropylacetoaldehyde Tosylhydrazone”Journal of the American Chemical Society, 90(25), 7167-8, 1968.
Tsuruta, et al., “β-(2,4,6-Cycloheptatrien-1-yl)ethylcarbene. The Synthesis of 9-Substituted bicyclo[4.2.1]nona-2,4,7-trienes and 9-Substituted Barbaralanes”Bulletin of the Chem. Soc. Of Japan, 45, 2822-2828, 1972.
Perevalov, et al., “Spectroscopic features of isomeric trans-styrylpyrazoles”,Khimiya Geterotsiklicheskikh Soedinenii, 1990, 8:1061-1064.
Chau-Hua, et al., “Hepatocyte Growth Factor Gene Therapy Prevents Radiation-Induced Liver Damage”, World Journal of Gastroenterology (2005), v. 11, No. 10, pp. 1496-1502.
Dohi, et al., “Hepatocyte Growth Factor Attenuates Collagen Accumulation in a Murine Model of Pulmonary Fibrosis”, Am. J. Respir. Crit. Care Med. (2000), v. 162, pp. 2302-2307.
Franquesa, et al., “Direct Electrotransfer of hHGF Gene into Kidney Ameliorates Ischemic Acute Renal Failure”, Gene Therapy (2005), v. 12, pp. 1551-1558.
Fujimoto, et al., “Hepatology: Microcirculation and Pathogenesis of Alcoholic Liver Injury”, Journal of Gastroenterology and Hepatology (2000), v. 15, pp. D33-D36.
Herrero-Fresneda, et al., “HFG Gene Therapy Attenuates Renal Allograft Scarring by Preventing the Profibrotic Inflammatory-induced Mechanisms”, Kidney International (2006), v. 70, pp. 265-274.
Hwang, et al., “A Single Administration of Adenoviral-Mediated HGF cDNA Permits Survival of Mice from Acute Hepatic Failure”, Life Sciences (2003), v. 72, pp. 851-861.
Jin, et al., “Early Treatment with Hepatocyte Growth Factor Improves Cardiac Function in Experimental Heart Failure Induced by Myocardial Infarction”, Journal of Pharmacology and Experimental Therapeutics (2003), v. 304, No. 2, pp. 654-660.
Lopez-Talavera, et al., “Hepatocyte Growth Factor Gene Therapy for Pancreatic Islets in Diabetes: Reducing the Minimal Islet Transplant Mass Required in a Glucocorticoid-Free Rat Model of Allogenic Portal Vein Islet Transplantation”, Endocrinology (2004), v. 145, No. 2, pp. 467-474.
Matsuno, et al., “Hepatocyte Growth Factor Gene Transfer into the Liver via the Portal Vein Using Electroporation Attenuates Rate Liver Cirrhosis”, Gene Therapy (2003), v. 10, pp. 1559-1566.
Morishita, et al., “Safety Evaluation of Clinical Gene Therapy Using Hepatocyte Growth Factor to Treat Peripheral Arterial Disease”, Hypertension (2004), v. 44, pp. 203-209.
Morishita, et al., “Therapeutic Angiogenesis Using Hepatocyte Growth Factor (HGF)”, Current Gene Therapy (2004), v. 4, pp. 199-206.
Nakagami, et al., “Hepatocyte Growth Factor Prevents Endothelial Cell Death Through Inhibition of Bax Translocation from Cytosol to Mitochondrial Membrane”, Diabetes (2002), v. 51, pp. 2604-2611.
Nakamura, et al., “Myocardial Protection from Ischemia/Reperfusion Injury by Endogenous and Exogenous HGF”, The Journal of Clinical Investigation (2000), v. 106, No. 12, pp. 1511-1519.
Numata, et al., “Hepatocyte Growth Factor Facilitates the Repair of Large Colonic Ulcers in 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats”, Inflamm Bowel Dis (2005), v. 11, No. 6, pp. 551-558.
Oe, et al., “Continuous Intravenous Infusion of Deleted Form of Hepatocyte Growth Factor Attenuates Hepatic Ischemia-Reperfusion Injury in Rats”, Journal of Hepatology (2001), v. 34, pp. 832-839.
Ono, et al., “Local Administration of Hepatocyte Growth Factor Gene Enhances the Regeneration of Dermis in Acute Incisional Wounds”, Journal of Surgical Research (2004), v. 120, pp. 47-55.
Powell, et al., “Therapeutic Angiogenesis for Critical Limb Ischemia: Design of the Hepatocyte Growth Factor Therapeutic Angiogenesis Clinical Trial”, Vascular Medicine (2004), v. 9, pp. 193-198.
Shimamura, et al., “Novel Therapeutic Strategy to Treat Brain Ischemia: Overexpression of Hepatocyte Growth Factor Gene Reduced Ischemic Injury Without Cerebral Edema in Rat Model”, Circulation (2004), v. 109, pp. 424-431.
Tashiro, et al., “Hepatocyte Growth Factor prevents Chronic Allograft Dysfunction in Liver-Transplanted Rats”, Transplantation (2003), v. 76, pp. 761-765.
Tsuzuki, et al., “Hepatocyte Growth Factor Reduces Infarct Volume After Transient Focal Cerebral Ischemia in Rats”, Acta Neurochir (2000), v. 76, pp. 311-316.
Ueki, et al., “Hepatocyte Growth Factor Gene T
Eiznhamer David A.
Zembower David E.
Anderson Rebecca
Angion Biomedica Corp.
Choate Hall & Stewart LLP
Grazier Nyeemah
Robidoux Andrea L.C.
LandOfFree
Small molecule modulators of hepatocyte growth factor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Small molecule modulators of hepatocyte growth factor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Small molecule modulators of hepatocyte growth factor... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3733089