Small molecule mimetics of erythropoietin

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical

Reexamination Certificate

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Details

C702S019000, C702S027000, C703S011000, C703S012000, C707S793000, C435S007100, C435S007200

Reexamination Certificate

active

11252390

ABSTRACT:
The invention features computer-assisted methods for identifying molecules which will bind to the EPO receptor and act as an erythropoietin (EPO) mimetic. Preferred EPO mimetics identified using the method of the invention act as agonists of the EPO receptor in one or more in vitro or in vivo biological assays of EPO activity.

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Livnah et al. “Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8. A” Science 273:464-471, 1996.
McCarthy, M. “Small Peptide Designed that can Mimic Erythropoietin” The Lancet 348:395, 1996.

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