Small molecule inhibitors of secretion of proteins encoded...

Details Small molecule inhibitors of secretion of proteins encoded... Small molecule inhibitors of secretion of proteins encoded...

2005-03-29

2005-03-29

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S153000

Reexamination Certificate

active

06872850

ABSTRACT:
The invention features compounds that inhibit secretion of a protein encoded by an ARE-mRNA or that modulate regulation of an ARE-mRNA. These compounds are useful for the treatment or prevention of conditions involving proteins encoded by ARE-mRNAs, such as TNFα.

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Cohen et al., “CNI-1493 Inhibits Monocyte/macrophage Tumor Necrosis Factor by Suppression of Translation Efficiency,”Proc. Natl. Acad. Sci. USA.1996, 93:3967-3971.
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