Small molecule inhibitors of kynurenine-3-monooxygenase

Details Small molecule inhibitors of kynurenine-3-monooxygenase Small molecule inhibitors of kynurenine-3-monooxygenase

2011-08-09

2011-08-09

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S227800, C514S236800, C514S254040, C514S326000, C514S370000, C544S060000, C544S133000, C544S367000, C546S209000

Reexamination Certificate

active

07994338

ABSTRACT:
The present invention relates to compounds of formula Ia or Ib below and their tautomers and/or pharmaceutically acceptable salts and compositions and methods of uses thereof.

REFERENCES:
patent: 2921066 (1960-01-01), Worffel et al.
patent: 3010872 (1961-11-01), Worffel et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5856347 (1999-01-01), Hashiguchi et al.
patent: 5877193 (1999-03-01), Cesura et al.
patent: 5958910 (1999-09-01), Cesura et al.
patent: 6191170 (2001-02-01), Medina
patent: 6207709 (2001-03-01), Varasi et al.
patent: 6583161 (2003-06-01), Medina
patent: 6645909 (2003-11-01), Fujita et al.
patent: 7183276 (2007-02-01), Sakai et al.
patent: 2005/0085518 (2005-04-01), Dai et al.
patent: 2006/0052456 (2006-03-01), Autier et al.
patent: 2006/0142358 (2006-06-01), Autier et al.
patent: 2008/0070937 (2008-03-01), Muchowski et al.
patent: 1121052 (1962-04-01), None
patent: 1249869 (1967-09-01), None
patent: 0610653 (1994-08-01), None
patent: 0819681 (1998-01-01), None
patent: 0 790 057 (2002-06-01), None
patent: 905369 (1962-09-01), None
patent: 2003/292485 (2003-10-01), None
patent: WO 90/09787 (1990-09-01), None
patent: WO 93/05014 (1993-03-01), None
patent: WO 99/28306 (1999-06-01), None
patent: WO 99/28309 (1999-06-01), None
patent: WO-03/072554 (2003-09-01), None
patent: WO 2005/79790 (2005-09-01), None
patent: WO 2005/103022 (2005-11-01), None
Chemical Abstracts Registry No. 894531-35-2, indexed in the file Registry on STN Jul. 19, 2006.
Chemical Abstracts Registry No. 402767-36-6, indexed in the file Registry on STN Mar. 25, 2002.
An English translation of JP 2003-292485, Oct. 15, 2003.
Ingle, D.B. et al. “Synthesis of 2-sulfanilamidothiazole derivatives and their antibacterial activity”. Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; XP002549764 retrieved from STN, Database accession No. 1979:38829.
Joshi, K.C. et al. “Organic Pesticides. Part X. Preparation of Some 2-Amino-4-aryl-5-alkylthiazoles and Related Compounds,N-Substituted Aminothiazoles and their Mercurials, and 2-p-Fluoro-phenylimino-4-thiazolidone and its Condensation Products” Journal of the Indian Chemical Society, The Indian Chemical Society, Calcutta, IN, vol. 39, No. 2, Jan. 1, 1962, pp. 121-128, XP000571711.
Khan, R.H. et al. “Synthesis of Fluoroarylthiazoles and Related Compounds as Possible Fungicides” Agricultural and Biological Chemistry, Japan Soc. for Bioscience, Biotechnology and Agrochem, Tokyo, JP, vol. 40, No. 6, Jan. 1, 1976, pp. 1129-1135, XP001026659.
Richter, A. et al. “The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.”European Journal of Pharmacology, 478 (2003) 47-52.
Rover, et al., J. Med. Chem. 1997, 40, 4378-4385.
R. Schwarcz and R. Pellicciari, The Journal of Pharmacology and Experimental Therapeutics, 2002, vol. 303, No. 1, pp. 1-10.
Bell, F. “Investigations in the Diphenyl Series. Part IX. Further Experiments with Sulphonamides” Journal of the Chemical Society, Chemical Society, Letchworth; GB LNKD-DOI:10.1039/JR9300001071, Jan. 1, 1930, pp. 1071-1077, XP009018773 ISSN: 0368-1769.
Bouchain, G. et al. “Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivates as Histone Deacetylase Inhibitors” Journal of Medicinal Chemistry, American Chemical Society, Washington, US LNKD-DOI:10.1021/JM020377A, vol. 46, Jan. 1, 2003, pp. 820-830, XP002278212. ISSN: 0022-2623.
Bouchain, G. et al. “Novel hydroxamate and anilide derivatives as potent histone deacetylase inhibitors: Synthesis and antiproliferative evaluation” Current Medicinal Chemistry, Bentham Science Publishers BV, BE LNKD-DOI:10.2174/0929867033456585, vol. 10, No. 22, Jan. 1, 2003, pp. 2359-2372, XP002480700, ISSN: 0929-8673.
Case, F. H. “Nitration of certain halo biphenyls. IV. Nitro derivatives of 3-bromobiphenyl” Journal of the American Chemical Society, Coden: JACSAT; ISSN: 0002-7863, vol. 67, 1945, pp. 116-121, XP002590239.
Dhanoa, D.S., et al. “Serine Proteases-Directed Small Molecule Probe Libraries” Medicinal Chemistry Research, Birkhaeuser, Boston, US, vol. 8, No. 4/05, Jan. 1, 1998, pp. 187-205, XP009016618, ISSN: 1054-2523.
El-Hewehi, Zaki. et al. “Sulfonic acid derivatives. III. Preparation, composition, and insecticide activity of sulfonamides” Journal Fuer Praktische Chemie (LEIPZIG), 34(5-6), 218-42 Coden: JPCEAO; ISSN: 0021-8383, 1966, XP009135712.
Erickson et al., A Radiometric Assay for Kynurenine 3-Hydroxylase Based on the Release of 3H2O During Hydroxylation of L-[3,5-3H]-Kynurenine, Anal. Biochem. 1992, 205, 257-262.
Finn, P.W. et al. “Novel Sulfonamide Derivatives as Histone Deacetylase” Helvetica Chimica Acta, Verlag Helvetica Chimica Acta, Basel, CH LNKD-DOI:10.1002/HLCA.200590129, vol. 88, Jul. 1, 2005, pp. 1630-1657, XP002367316. ISSN: 0018-019X.
Raju, B. et al. “Solid Phase Synthesis of Sulfonamides Using a Carbamate Linker” Tetrahedron Letters, Elsevier, Amsterdam, NL LNKD-DOI:10.1016/S0040-4039(97)00652-7, vol. 38, No. 19, May 12, 1997, pp. 3373-3376, XP004061429, ISSN: 0040-4039.
Somaglino, J. C. “Sulfonamides” Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; 1941, XP002590240.

Affiliated with

Also associated with

Rating

Small molecule inhibitors of kynurenine-3-monooxygenase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Small molecule inhibitors of kynurenine-3-monooxygenase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Small molecule inhibitors of kynurenine-3-monooxygenase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2788795