Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-08-11
2010-11-02
Padmanabhan, Sreeni (Department: 1627)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S438000, C514S461000, C549S029000
Reexamination Certificate
active
07825154
ABSTRACT:
Disclosed herein are methods of inhibiting the activity of Botulinum neurotoxin A metalloprotease with the compounds disclosed herein. Also disclosed are methods of treating, inhibiting or preventing intoxication caused by bacteria of at least one bacterial strain in a subject, and pharmaceutical and cosmetic compositions comprising the compounds disclosed herein.
REFERENCES:
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Weidner-Wells et al. “Amidono Benimidazole Inhibitors of Bacerial Two-Component Systems” Bioorganic & Medicinal Chemistry Letters, 2001, vol. 11, pp. 1545-1548.
Mota-Meira et al. “MICs of Mutacin B-Ny266, Nisin A, Vancomycin, and Oxacillin against Bacterial Pathogens” Antimicrobial abents and chemotherapy, Jan. 2000, pp. 24-29.
Anne, J. et al. (1980) “Antifungal and Antibacterial Activities of Diarylamidine Derivatives” Antimicrobial Agents & Chemotherapy 18(2):231-239.
De. Clercq et al. (1980) “Diary1 Amidine Derivatives as Oncornaviral DNA Polymerase Inhibitors” J. Med. Chem. 23:787-795.
Tidwell et al. (1978) “Diarylamidine Derivatives with One or Both of the Aryl Moieties Consisting of an Indole or Indole-like Ring, Inhibitors of Arginine-Specific Esteroproteases” J. Med. Chem. 21(7):613-623.
Bavari Sina
Burnett James C.
Gussio Rick
Arwine Elizabeth
Carter Kendra D
Padmanabhan Sreeni
The United States of America as represented by the Secretary of
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