Small molecule inhibition of RNA/ligand binding

Details Small molecule inhibition of RNA/ligand binding Small molecule inhibition of RNA/ligand binding

1995-03-02

1999-08-10

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435238, 514471, C12Q 170, C12Q 168, A01N 4308, A61K 3134

Patent

active

059357762

ABSTRACT:
Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemplified by

REFERENCES:
patent: 4619942 (1986-10-01), Tidwell et al.
patent: 4933347 (1990-06-01), Tidwell et al.
Zhao et al (1995) Bioorg. Med. Chem. 3(6):785-94.
Marcus et al (1985) Cancer Res. 45(1):112-15.
Uwe von Ahsen et al., "Non-competitive Inhibition of Group I Intron RNA Self-splicing by Aminoglycoside Antibiotics", J. Mol. Biol., 226:935-941 (1992).
Michael H. Malim et al., "Functional Dissection of the HIV-1 Rev Trans-Activator-Derivation of a Trans-Dominant Repressor of Rev Function", Cell, vol. 58, pp. 205-214, (1989).
Roger J. Pomerantz et al., "Cells Nonproductively Infected with HIV-1 Exhibit an Aberrant Pattern of Viral RNA Expression: A Molecular Model for Latency", Cell, vol. 61, pp. 1271-1276, (1990).
David P. Bartel et al., "HIV-1 Rev Regulation Involves Recognition of Nion-Watson-Crick Base Pairs in Viral RNA", Cell, vol. 67, pp. 529-536, (1991).
Seth Stern et al., "The Herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain", Genes & Development vol. 5, pp. 2555-2566, (1991).
Nelson L. Michael et al., "Induction of Human Immunodeficiency Virus Type 1 Expression in Chronically Infected Cells is Associated Primarily with a Shift in RNA Splicing Patterns", Journal of Virology, 65, pp. 1291-1303, (1991).
Otto Dann et al., "Trypanocide Diamidine mit drei isolierten Ringsystemen", Liebigs Ann. Chem, pp. 160-194, (1975).
Bijan P. Das et al., "Synthesis and Antiprotozoal Activity of 2,5-Bis(4-guanylphenyl)furans", Journal of Med. Chemistry, vol. 20, No. 4, pp. 531-536, (1977).
Paulette A. Greenidge et al., "DNA Minor Groove Recognition Properties of Pentamidine and its Analogs: A Molecular Modeling Study", Molecular Pharmacology, vol. 43, pp. 982-988.
Constance A. Bell et al., "Structure-Activity Relationships of Pentamidine Analogs against Giardia Lamblia and Correlation of Antigiardial Activity with DNA-Binding Affinity", Antimicrobial Agents and Chemotherapy, 35, pp. 1099-1107, (1991).
David W. Boykin et al., "Dicatiionic Diarylfurans as Anti-Pneumocystis carinii Agents", J. Med. Chem., vol. 38, pp. 912-916, (1995).
W. David Wilson et al., "The Search for Structure-Specific Nucleic Acid-Interactive Drugs: Effects of Compound Structure of RNA versus DNA Interaction Strength", Biochemistry, vol. 32, pp. 4098-4104, (1993).

Affiliated with

Also associated with

Rating

Small molecule inhibition of RNA/ligand binding does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Small molecule inhibition of RNA/ligand binding, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Small molecule inhibition of RNA/ligand binding will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1119048