Small molecule inhibition of RNA/ligand binding

Details Small molecule inhibition of RNA/ligand binding Small molecule inhibition of RNA/ligand binding

1997-08-13

2000-02-01

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

548566, 558371, 558375, C07D26530, C07D20708, C07D25500

Patent

active

060204885

ABSTRACT:
Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemplified by 2,5-Bis[3-(2-N,N-dimethylaminopropylamidino)phenyl]furan.

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Tilley, J.W. et al, J. Med. Chem. 1989, 32, pp. 1814-1820.
Lee, Y.J. et al, Tetrahedron Lett. 1993, 34(37), pp. 5855-5858.
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March, J., Advanced Organic Chemistry, 1992, 4th edition, John Wiley & Sons Inc., pp. 601-603.
Boykin, David W. et al., "2,5-Bis[4-(N-alkylamidino)phenyl]furans as Anti-Pneumocystis carinii Agents", J. Med. Chem. 41:1 124-129 (1998).
Hendrix, M. et al., "Direct Observation of Aminoglycoside-RNA Interactions by Surface Plasmon Resonance", J. Med. Chem. 119:16 3641-3648 (1997).

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