Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-10-11
2009-10-13
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S509000
Reexamination Certificate
active
07601750
ABSTRACT:
Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formulaThe invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds.Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
REFERENCES:
patent: 5260322 (1993-11-01), Nakasima et al.
patent: 5852046 (1998-12-01), Lang et al.
patent: 6069156 (2000-05-01), Oku et al.
patent: 6265547 (2001-07-01), Yue et al.
patent: 6358992 (2002-03-01), Pamukcu et al.
patent: 2002/0137129 (2002-09-01), Barnes et al.
patent: 0624628 (1994-11-01), None
patent: 0639573 (1995-02-01), None
patent: 05-28172 (1993-10-01), None
patent: 11-180801 (1999-07-01), None
patent: WO 97/48697 (1997-12-01), None
Vippagunta et al., Crystalline solids, 2001, Advanced Drug Delivery Reviews, 48, pp. 3 and 18.
Fluorescent labelling [online], Retrieved from the Internet Aug. 14, 2008, www.en.wikipedia.org/wiki/Fluorescent labelling.
Fuji et al., “Targeting PDZ-domain by rationally designed non-peptide small molecules”, poster presentation at a conference of the American Society of Cell Biology, Dec. 2002.
Harris et al., “Mechanism and role of PDZ domains in signaling complex assembly”; Journal of Cell Science, 2001, vol. 114 pp. 3219-3231.
Hulme et al., The Synthesis and biological evaluation of a novel series of indole PDE4 inhibitors, 1998, Bioorganic & Medicinal Chemistry Letters, vol. 8 pp. 1867-1872.
Lee et al., “Multi-PDZ domain protein MUPP1 is a Cellular Target . . . ”, Journal of Virology, 2000, vol. 74 pp. 6980-9693.
Novak et al., Investigation of the PDZ domain ligand site using chemically modified peptides, 2002, Bioorganic & Medicinal Chemistry Letters, vol. 12 pp. 2471-2474.
Novak et al., Fishing-up PDZ by tagged-FJ-3; slide presented at a conference of the American Chemical Society, Mar. 2003.
Novak et al., “Small molecule inhibition of a PDZ domain interaction”, poster presented at a conference of the American Society of Biochemistry and Molecular Biology, Apr. 15, 2003.
Ponting et al., “PDZ domains: targeting signalling molecules to sub-membranous sites”, 1997, BioEssays vol. 19 pp. 469-479.
Shibata et al., “EBP50, a beta-catenin-associating protein, enhances Wnt signaling . . . ”, 2003, Heptatology, vol. 38 pp. 178-186.
Stemmer-Rachamimov et al., “NHE-RF, A Merlin-interacting protein, is primarily expressed in . . . ”, 2001, American Journal of Pathology, vol. 158 pp. 57-62.
Uematsu et al., “Wnt pathway Activation in mesothelioma”, 2003, Cancer Research vol. 63 pp. 4547-4551.
Uematsu et al., Activation of the Wnt pathway in non small cell lung cancer, 2003, Oncogene, vol. 22 pp. 7218-7221.
Wong et al., Direct bonding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzle, 2003, vol. 12 pp. 1251-1260.
Xing, Chengguo et al.; “Design of Cancer-Specific Antitumor Agents Based on Aziridinylcyclopent[b]indoloquinones”; 2000,J. Med. Chem., vol. 43, pp. 457-466.
Fujii Naoaki
Guy R. Kiplin
Haresco Jose
He Biao
Jablons David M.
Bianchi Kristin
Bozicevic Field & Francis LLP
Francis Carol L.
Saeed Kamal A
The Regents of the University of California
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