Small conductance, calcium-activated potassium channels (SK 3)

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

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06987169

ABSTRACT:
This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositions for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.

REFERENCES:
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Kohler et al., Small-Conductance, Calcium-Activated Potassium Channels for Mammalian Brian,SCIENCE, 273:1709-1714 (Sep. 1996).
Database EMBL 'Online!, Oct. 4, 1996 Database accession No. U69883, XP002212554, the whole document.
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Database EMBL 'Online!, Oct. 4, 1996 Database accession No. U69882, XP002212556, the whole document.
Database Swissport 'Online!, Nov. 1, 1996, Database accession No. Q19186, XP002212558, the whole document.
McCobb D P et al.: “A Human Calcium-Activated Potassium Channel Gene Expressed in Vascular Smooth Muscle”, American Journal of Physiology: Heart and Circulatory Physiology, The American Physiology Society, XX, vol. 269, NR. 3, pp. H767-H777 XP00292414, ISSN: 0363-6135.

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