Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-01-01
2008-01-01
Ungar, Susan (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S350000, C530S387100
Reexamination Certificate
active
07314721
ABSTRACT:
Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in small cell lung cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with small cell lung cancer. The invention provides, among other things, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
REFERENCES:
patent: 5698396 (1997-12-01), Pfreundschuh
patent: WO 95/03422 (1995-02-01), None
patent: WO 99/57438 (1999-10-01), None
patent: WO 99/60160 (1999-11-01), None
Tockman et al (Cancer Res.. 1992, 52:2711s-2718s).
Slamon et al. (Science vol. 235, Jan. 1987, pp. 177-182).
Janeway and Travers (Immunobiology: The Immune System in Health and Disease, 1994, pp. 9:40-42.
Stevanovic, M. et al.,Mammalian Genome5:640-642 (1994).
Collignon, J. et al.,Development122:509-520 (1996).
Graus, F. et al,Journal of Clinical Oncology15:2866-2872 (1997).
Johnson, L. et al.,Molecular Reproduction and Development50:377-386 (1998).
Malas, S. et al.,Mammalian Genome10:934-937 (1999).
Ohwada, A. et al.,Am. J. of Respir. Cell and Mol. Biol. 21:37-43 (1999).
Graham, J.D. et al.,Journal of Molecular Endocrinology22:295-304 (1999).
Manda, R. et al.,Genomics61:5-14 (1999).
Scanlan, M. et al.,Int. J. Cancer83:456-464 (1999).
Gure, A. et al.,Proc. Natl. Acad. Sci. USA97:4198-4203 (2000).
Sahin et al.,Proc. Natl. Acad. Sci USA92:11810-11813 (1995).
Chen et al.,Proc. Natl. Acad. Sci. USA94:1914-8 (1997).
Carney et al.,Cancer Res. 45:2913-2923, 1985.
Park et al.,Cancer Res. 47:6710-6718 (1987).
Old and Chen,J. Exp. Med., 187:1163-7 (1998).
Chen et al.,Proc. Nat'l. Acad. Sci. USA, 95: 6919-23 (1998).
Scanlan et al.,Int. J. Cancer76:652-658 (1998).
Riechmann et al.,Nucleic Acids Res. 22: 749-755 (1994).
Shoji et al.,J. Biol. Chem., 270:24818-25 (1995).
Matsumoto-Taniura et al.Mol. Biol. Cell, 7: 1455-69 (1996).
Triebel et al.,J. Exp. Med., 171: 1393-1405 (1990).
Stockert et al.,J. Exp. Med. 187:1349-1354 (1998).
Dalmau & Posner,Arch. Neurol. 56:405-408 (1999).
Posner & Dalmau,Curr. Opin. Immunol. 9:723-729 (1997).
Carpentier et al.,Clin. Cancer Res. 4:2819-2824 (1998).
Stevanovic, M. Genbank Acc. No. Z31560. “H. Sapiens sox-2 mRNA (partial)”, base pairs 1-500, Jul. 28, 1995.
Malas S. Genbank Acc. No. Y13436. “Homo sapiens sox1 gene”, base pairs 1-500, May 28, 1997.
Kiesling, T.L. Genbank Acc. No. U28368. “Human ID-related helix-loop-helix protein Id4 mRNA, complete cds” base pairs 1-500, Aug. 3, 1995.
Bossone, S.A. et al. Genbank Acc. No. M94046. “Human Zinc Finger Protein (Max) MRNA”. Base Pairs 1-500. Apr. 27, 1993.
Matsumoto-Taniura, N. et al. Genbank Acc. No. X98260. “H. sapiens mRNA for M-phase phosphoprotein, mpp11”. Base pairs 1-500. Jan. 8, 1997.
Asuru, A.I. et al. Genbank Acc. No. U23028. “Human eukaryotic initiation factor 2B-epsilon mRNA, partial cds.” Base pairs 1-500. Aug. 22, 1996.
Amakawa, R. et. al. Genbank Acc. No. L07872. “Homo sapiens recombination signal binding protein (RBPJK) mRNA, partial cds.” Base pairs 1-500, 1993.
Pardoll et al., Cancer vaccine, May 1998, Nature Medicine Vaccine Supplement, vol. 4, No. 5, pp. 525-531.
Malas, S. et al. Genbank Acc. No. AF107044. “Homo sapiens clone pCL4 DNA-binding protein SOX21 (SOX21) gene. complete cds.” Base pairs 1-500. Dec. 13, 1998.
Ohara, O. et al. Genbank Acc. No. AB023180. “Homo sapiens mRNA for KiAA0963 protein, complete cds.” Jun. 16, 1999.
Triebel, F. et al., Genbank Acc. No. X51985. “Human LAG-3 mRNA for CD4-related protein involved in lymphocyte activation.” 1990.
Koehrer, K. et al. Genbank Acc. No. AL133561. Homo sapiens mRNA, cDNA DKFZp434C196 (from clone DKFZp434C196). base pairs 1-500. Dec. 15, 1999.
Vural et al.,Cancer2005; 103:2575-2538.
Chen Yao-tseng
Gure Ali O.
Jager Dirk
Old Lloyd J.
Scanlan Matthew J.
Ludwig Institute for Cancer Research
Memorial Sloan-Kettering Cancer Center
New York Hospital-Cornell Medical Center
Redig Peter J.
Ungar Susan
LandOfFree
Small cell lung cancer associated antigens and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Small cell lung cancer associated antigens and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Small cell lung cancer associated antigens and uses therefor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2762848