Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1994-10-26
1997-07-01
Stanton, Brian R.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
424 92, 424 931, 424 933, 424520, 424529, 424578, 424582, 424900, 4351723, 800 2, A01N 5700, A61K 3800, C12N 500, C12N 1506
Patent
active
056435517
ABSTRACT:
A method for initiating metastasis of human tumor cells under experimental conditions is provided. Immunocompromised non-human mammals having a viable, xenogeneic organ or tissue are used as a host for human tumor cells. The cells are introduced into the chimeric animal after the solid tissue is implanted and are then able to grow and metastasize as they would in situ. Therapeutic regimens may be evaluated in this system to determine efficacy against metastatic processes.
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Kyoizumi Seishi
McCune Joseph M.
Namikawa Reiko
Shtivelman Emilya
Sherwood Pamela J.
Stanton Brian R.
Systemix, Inc.
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