Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1998-05-20
2000-08-15
Carlson, Karen Cochrane
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
530329, 530328, 530327, 530326, 530300, 530350, C07K 1400
Patent
active
061038695
ABSTRACT:
The invention describes amino acid residues of the Smad2 protein which are important for phosphorylation and activity, and Smad2 polypeptide fragments and biologically functional variants thereof. Included and dominant-negative variants of Smad2 and antibodies relating thereto. Also included are nucleic acids which encode such variants. Antibodies which selectively bind pathway-restricted Smad proteins phosphorylated at the C-terminal tail also are provided. Methods and products for using such nucleic acids and polypeptides also are provided.
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Engetrom Ulla
Heldin Carl-Henrik
Piek Ester
Souchelnytokyi Serhiy
Tamaki Kiyoshi
Carlson Karen Cochrane
Ludwig Institute for Cancer Research
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