Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1988-08-25
1990-11-20
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424458, 424459, 424462, 424468, 424480, 424482, 424495, 424497, A61K 958
Patent
active
049718053
ABSTRACT:
Slow-releasing granules which are characterized by coating the quick-releasing granules which comprise an active ingredient, polyvinyl pyrrolidone polymer and a disintegrator where the polymer distributes in high concentration on the surface area of the granules, with a polyacid enteric material to form a complex between the polyvinyl pyrrolidone polymer and the polyacid, and long lasting mixed granules which comprise the quick-releasing granules and the slow-releasing granules, thus showing increased bioavailability of the active ingredient and high stability sustained for a long period of time.
REFERENCES:
patent: 2410417 (1946-11-01), Andersen
patent: 4794001 (1988-12-01), Mehta et al.
Kitanishi Yasuhisa
Kochi Tsuyoshi
Taniguchi Hiroaki
Page Thurman K.
Teysan Pharmaceuticals Co., Ltd.
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