Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1991-10-15
1995-05-02
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
424405, 424486, A01N 2534
Patent
active
054117372
ABSTRACT:
There is disclosed a slow release drug delivery device for the prolonged administration of topically active medicines which consists of a vehicle in which water is soluble and in which is dissolved the topically active drug which is formed into a stable organogel with a polymer matrix with a very low water absorbing capability. The organogel, in the presence of water or atmospheric water vapor, slowly imbibes such water into the vehicle and by doing so the vehicle becomes incompatible with the matrix and is slowly expelled therefrom. The vehicle dissolves the drug and the vehicle/drug combination is slowly pumped out of the polymeric matrix with substantially linear drug delivery occurring for periods in excess of 6 months. The drug delivery device may be used to administer drugs topically, as a collar or trans dermal patch, orally, as a slow delivery device, particularly as a ruminal bolus, or as a suppository or a subcutaneous implant. The preferred form for the drug delivery device is as a flea and tick collar for household pets and the preferred active drug is selected from the avermectin and milbemycin families of active antiparasitic agents.
REFERENCES:
patent: 3318769 (1967-05-01), Folckemer et al.
patent: 3921636 (1975-11-01), Zaffaroni
patent: 3944662 (1976-05-01), Miller et al.
patent: 4717718 (1988-01-01), Eckenhoff et al.
patent: 4965287 (1990-10-01), Stendel et al.
Mrozik, Helmut et al. Synthesis & Biological Activities of B-Substituted Avermectin Aglycons, J. Med. Chem. 1989, 32, 375-381.
Cardarelli in Controlled Release Technologies, Methods, Theory and Applications Kydonieus (Ed) CRC Publishing vol. 1, pp.57-59 (1980).
Sears, et al in Encyclopedia of PVC, vol. 1, pp. 474-510.
The Merck Index--Eleventh Edition--p. 1342 (1989).
Hsu Terry T.
Michaels Alan S.
DiPrima Joseph F.
Levy Neil
Merck & Co. , Inc.
Page Thurman K.
Rose David L.
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