Slow-release sodium fluoride tablet, method of making, and metho

Details Slow-release sodium fluoride tablet, method of making, and metho Slow-release sodium fluoride tablet, method of making, and metho

1986-03-21

1988-02-23

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424151, 424498, 424502, A61K 922, A61K 926, A61K 3316

Patent

active

047269529

ABSTRACT:
A novel use for a slow-release sodium fluoride preparation. Such slow-release sodium preparation is shown to provide a safe but effective level of fluoride in serum, optimal for the treatment of osteoporosis. It minimizes gastrointestinal side effects by limiting the amount of fluoride released in the stomach and it reduces rheumatic complications by avoiding toxic levels of fluoride in serum. The amount of fluoride absorbed is nevertheless sufficient to stimulate bone formation and prevent fractures. Thus, the maintenance of serum fluoride as encompassed in this invention, allows for a safe and effective treatment of osteoporosis.

REFERENCES:
patent: Re24090 (1955-11-01), Diamond
patent: 3062270 (1962-11-01), Costello
patent: 3108046 (1963-10-01), Harbit
patent: 3279998 (1966-10-01), Raff et al.
patent: 3402240 (1968-09-01), Cain et al.
patent: 3577514 (1971-05-01), Robinson
patent: 4104370 (1978-08-01), Bloch
patent: 4169885 (1979-10-01), Raaf et al.
Ekstrand et al., Europ. J. Clin. Pharmacol. 12:311-317, (1977), "Pharmacokinetics of Fluoride in Man After Single and Multiple Oral Doses".
Hasvold and Ekren, Eur. J. Clin. Pharmacol., vol. 19, pp. 225-230, (1981).

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