Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1987-10-22
1990-02-27
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424469, 424470, 424484, 424502, A61K 922, A61K 926
Patent
active
049044788
ABSTRACT:
A novel slow-release sodium fluoride preparation and its use. Such slow-release sodium preparation comprises carnauba wax and talc and may be used to provide a safe but effective level of fluoride in serum, optimal for the treatment of osteoporosis. Gastrointestinal side effects are minimized by limiting the amount of fluoride released in the stomach and rheumatic complications are reduced by avoiding toxic levels of fluoride is serum. The amount of fluoride absorbed is nevertheless sufficient to stimulate bone formation and prevent fractures. Thus, the maintenance of serum fluoride as encompassed in this invention, allows for a safe and effective treatment of osteoporosis.
REFERENCES:
patent: 3062720 (1962-11-01), Costello
patent: 3402240 (1968-09-01), Cain et al.
patent: 3577514 (1971-05-01), Robinson
patent: 3653914 (1972-04-01), Schmitt
patent: 4104370 (1978-08-01), Bloch
patent: 4185093 (1980-01-01), Carnes et al.
patent: 4405596 (1983-09-01), Helbig et al.
patent: 4614648 (1986-09-01), Bru
patent: 4726952 (1988-02-01), Walsdorf et al.
Reg. T.M. 1,300,132, Reg. 10/16/1984, Slow Fluoride, (Mission Pharmacal), (First Use in Commerce, Nov. 19, 1982).
Walsdorf, Aug. 14, 1985, Sworn Statement of Formula of Slo-Fluoride.TM. Tablet, Sodium Fluoride 25 mg., Carnauda Wax 100 mg., Talc 11 mg., Sugar 90 mg., Magnesium Stratate 4 mg.
Pak et al., J. Bone & Mineral Res., 1(6): 563-571, (1986).
Hasvold et al., "In Vitro Release and in Vivo Serum Fluoride Levels and Urinary Excretion After Different Sodium Fluoride Tablets", European Journal of Clinical Pharmacology, 1981, pp. 225-230.
Moller et al., "Massive Fluorosis of Bones and Ligaments", University's Roentgen Clinic, State Hospital, Copenhagen, 1932, pp. 269-294.
Farley et al., "Fluoride Directly Stimulates Proliferation and Alkaline Phosphatase Activity of Bone-Forming Cells", Science, vol. 222, pp. 330-332.
Jowset et al., "Effect of Combined Therapy with Sodium Fluoride, Vitamin D and Calcium in Osteoporosis", The American Journal of Medicine, vol. 53, Jul. 1972, pp. 43-49.
Pekkanen, "The Hidden Health Risk Most Women Face", Reader's Digest, Nov. 1985, pp. 72-77.
The Consensus Development Conference Statement, "Osteoporosis", Apr. 2-4, 1984.
Butz et al., "Influence of Alkaline Salts and Acetazoleamide on Urinary Excretion of Citrate and Oxalate in the Rat", Abstracts of the 5th Symposium on Experimental Urology, 1980.
Pak et al., "The Hypercalciurias Causes, Parathyroid Functions, and Diagnostic Criteria", The Journal of Clinical Investigation, vol. 54, Aug. 1974, pp. 387-400.
Bishop, "America's New Hunger for Calcium Presents a Nutritional Dilemma", The Wall Street Journal, 1986.
Christiansen et al., "Does Calcium Treatment Prevent Postmenopausal Bone Loss? A Double-Blind Controlled Clinical Trail", Journal of Bone and Mineral Research, 1:166A, 1986.
Matkovic et al., "Influence of Calcium on Peak Bone Mass: A Pilot Study", Journal of Bone and Mineral Research, 1:166A, 1986.
Riggs et al., "In Women Dietary Calcium Intake and Rates of Bone Loss from Midradius and Lumbar Spine Are Not Related", Journal of Bone and Mineral Research, 1:166A, 1986.
Skillman, M.D., "Management for all Women, Prevention for Some", Consultant, Feb. 1984, pp. 153-165.
Belizan M.D. et al., "Reduction of Blood Pressure with Calcium Supplementation in Young Adults", JAMA, Mar. 4, 1983, vol. 249, No. 9, pp. 1161-1165.
Riggs et al., "Effect of the Fluoride/Calcium Regimen on Vertebral Fracture Occurrence in Postmenopausal Osteoporosis", The New England Journal of Medicine, Feb. 25, 1982, pp. 446-450.
Nordin et al., "Treatment of Spinal Osteoporosis in Postmenopausal Women", British Medical Journal, Feb. 16, 1980, pp. 451-454.
Heaney et al., "Menopausal Changes in Calcium Balance Performance", J. Lab. Clin. Med., Dec. 1978, pp. 953-963.
Recker et al., "Efforts of Estrogens and Calcium Carbonate on Bone Loss in Postmenipausal Women", Annals of Internal Medicine, vol. 87, No. 6, Dec. 1977, pp. 649-655.
Pak Charles Y. C.
Walsdorf Neill B.
Board of Regents , The University of Texas System
Mission Pharmacal Company
Rose Shep K.
LandOfFree
Slow-release sodium fluoride tablet and method for treatment of does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Slow-release sodium fluoride tablet and method for treatment of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Slow-release sodium fluoride tablet and method for treatment of will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-172814