Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2011-03-29
2011-03-29
Sheikh, Humera N (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S423000, C424S426000, C424S464000, C424S468000, C424S489000
Reexamination Certificate
active
07914804
ABSTRACT:
A pharmaceutical preparation adopted for sustained release of an active agent(s) over an extended period of time at a therapeutic rate without an initial burst release of the agent(s) upon administration, wherein the preparation comprises: (i) an outer portion prepared from one or more layers of a biodegradable polymer, which is selected to release an active agent over an extended period of time when positioned in situ in a patient, and (ii) an inner portion comprising a plurality of micro-capsules formed from at least a biodegradable polymer, said micro capsules containing at least an active agent, wherein the micro-capsules are compressed into the form of a tablet under suitable pressure to suppress the rate of release of the active agent from the micro-capsules. The present specification also relates to a method for inserting one or more implants(s) into a tissue of a mammal comprising the following steps: a) making a small incision into the tissue with a needle and a first sheath; b) withdrawing the needle from the first sheath but leaving the first sheath in the tissue; c) dilating the opening of the incision by inserting a dilator and second sheath of larger diameter through the body of the first sheath; d) withdrawing the dilator from the second sheath, but leaving the second sheath in the tissue; e) disturbing the implant(s) from a sheath filled with implant(s) by inserting said sheath into the final sheath inserted into the tissue and pushing a dilator into the sheath thereby releasing said implant(s) into the tissue.
REFERENCES:
patent: 3523906 (1970-08-01), Vrancken et al.
patent: 3737337 (1973-06-01), Schnoring et al.
patent: 4351337 (1982-09-01), Sidman
patent: 5183464 (1993-02-01), Dubrul et al.
patent: 5304119 (1994-04-01), Balaban et al.
patent: 5503851 (1996-04-01), Mank et al.
patent: 5817343 (1998-10-01), Burke
patent: 6203813 (2001-03-01), Gooberman
patent: 1598458 (1981-09-01), None
patent: 2 103 927 (1983-03-01), None
patent: WO 97/27843 (1997-08-01), None
patent: WO 00/02616 (2000-01-01), None
I. Soriano and C. Evora, “Formulation of calcium phosphates/poly (d,l-lactide) blends containing gentamicin for bone implantation,” Journal of Controlled Release, Elsevier Science Publishers, B.V. (Amsterdam, The Netherlands), vol. 68 ( No. 1), p. 121-134, (Jul. 17, 2000).
Schwope, A.D., et al., “Lactic/glycolic acid polymers as narcotic antagonist delivery systems,” Life Sciences, vol. 17 ( No. 12), p. 1877-1885, (Nov. 17, 1975).
Harrigan, S.E., et al., “Pharmacological Evaluation of Narcotic Antagonist Delivery Systems in Rhesus Monkeys”, NIDA Research Monograph, vol. 28, 1981, pp. 77-92.
Reuning, R.H. et al., “Pharmacokinetic Quantitation of Naltrexone Release From Several Sustained-Relsease Delivery Systems”, NIDA Research Monograph, vol. 28, 1981, pp. 172-184.
Liu Yandi
O'Neil Alexander George B.
Fredrikson & Byron , P.A.
Palmaya Pty Ltd
Sheikh Humera N
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