Slow release drug delivery granules and process for production t

Details Slow release drug delivery granules and process for production t Slow release drug delivery granules and process for production t

1989-12-28

1991-10-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424502, 424496, 424497, 424498, 424499, 424500, 424501, A61K 916

Patent

active

050553070

ABSTRACT:
Slow release drug delviery granules comprising porous granules of a calcium phosphate compound having an atomic ratio of Ca to P of 1.3 to 1.8, a porosity of 0.1 to 70%, a specific surface area of 0.1 to 50 m.sup.2 /g and a pore size of 1 nm to 10 .mu.m, fired at a temperature of 200.degree. to 1400.degree. C., and a drug component impregnated in pores of the granules, and a process for producing the same. The drug delivery granules of the present invention have a controllable, prolonged effect of drug release and a good imaging property to an X-ray or ultrasonic wave, and therefore can be advantageously utilized in the field of chemotherapy.

REFERENCES:
patent: 4322398 (1982-03-01), Reiner et al.
patent: 4341759 (1982-07-01), Bogentoft
patent: 4675188 (1987-06-01), Chu
patent: 4707361 (1987-11-01), Gustafson
patent: 4720384 (1988-01-01), DiLuccio
patent: 4761366 (1988-08-01), Nakajima
patent: 4781904 (1988-11-01), Tagaya
patent: 4840799 (1989-06-01), Appelgren
patent: 4865733 (1989-09-01), Tsuru
patent: 4892738 (1990-01-01), Takagishi
patent: 4935247 (1990-06-01), Marttila
patent: 4937080 (1990-06-01), Appelgren
Copy of Australian Patent Abstract AU-A-10240/83.
An English language abstract of Japanese Unexamined Patent Publication No. 61-47401.
An English language abstract of Japanese Unexamined Patent Publication No. 55-122710.

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