Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-01-04
2008-08-12
Pak, Michael (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07411043
ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4.
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Joiner et al., “Formation of intermediate-conductance calcium activated potassium channels by interaction of Slack and Slo subunits,”Nature Neuroscience, Oct. 1998, pp. 462-469, vol. 1(6).
Nagase, Takahiro et al.; “Prediction of the Coding Sequences of Unidentified Human Genes. XVI. The Complete Sequences of 150 New cDNA Clones from Brain which Code for Large Proteins in vitro”; 2000,DNA Research, vol. 7, pp. 65-73.
“Homo sapiensmRNA for KIAA1422 protein, partial cds”; 2000, EBI accession No. EM—HUM:AB037843, database accession No. AB037843.
“hh76g10.x1 NCI—CGAP—GU1Homo sapienscDNA clone Image: 2968770 3′ similar to TR: Q9z258 Q9Z258 Potassium Channel Subunit, mRNA sequence”; 2000, EBI accession No. EM—EST: AW615027, database accession No. AW615027.
Jegla Timothy James
Witzel Julie Dickson
Icagen Inc.
Pak Michael
Townsend and Townsend / and Crew LLP
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