Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-12-06
2011-10-25
Barnhart, Lora E (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S325000
Reexamination Certificate
active
08043803
ABSTRACT:
The present invention relates to slitrk proteins as markers of stem and progenitor cells, including embryonic stem cells and hematopoietic stem and progenitor cells, and also as a marker of leukemia and lymphoma cells, and of endothelial cells. The invention provides, inter alia, methods for purifying slitrk-positive cells, methods for detecting slitrk-positive cells, purified preparations of slitrk-positive cells, therapeutic compositions containing purified slitrk-positive cells, methods for targeting therapeutic agents to slitrk-positive cells, and methods of treatment, including but not limited to, methods of administering slitrk-positive cells to subjects in need thereof.
REFERENCES:
patent: 5514539 (1996-05-01), Bukh et al.
patent: 6670123 (2003-12-01), Belyavsky et al.
Hackney JA et al. 2002. A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci USA 99: 13061-13066.
Terskikh AV et al. 2001. From hematopoiesis to neuropoiesis: Evidence of overlapping genetic programs. Proc Natl Acad Sci USA 98: 7934-7939.
Abelson et al., “Sequence variants in slitrkl are associated with Tourette's syndrome,” Science;3 10(5746):3 17-320 (Oct. 14, 2005).
Aruga et al., “Human slitrk family genes: genomic organization and expression profiling in normal brain and brain tumor tissue,” Gene;3 1537-94 (Oct. 2, 2003).
Aruga et al., “Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth,” Mol Cell Neurosci;24(1): 117-129 (Sep. 2003).
Asahara et al., “Isolation of putative progenitor endothelial cells for angiogenesis.” Science;275(5302):964-967 (Feb. 14, 1997).
Baum et al.,.“Isolation of a candidate human hematopoietic stem-cell population,” Proc Natl Acad Sci U S A;8(7):2804-2808 (Apr. 1, 1992).
Bonnet et al., “Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell,” Nat Med.;3(7):730-737 (Jul. 1997).
Civin et al., “Antigenic analysis of hematopoiesis. 111. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-la cells,” J Immunol.; 133(1): 157-165 (Jul. 1984).
Folkman J., Angiogenesis-dependent diseases. Semin Oncol.;28(6):536-542 (Dec. 2001).
Goodell et al., “Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo,”J Exp Med.;183(4): 1797-1806 (Apr. 1, 1996).
Nador et al., “Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus,”;88(2):645-656 (Jul. 15, 1996).
Okada et al., “Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule,” Blood.;78(7): 1706-1712 (Oct. 1, 1991).
Osawa et al., Long-term lymphohematopoietic reconstitution by a single CD34-lowlnegative hematopoietic stem cell, Science;273(5272):242-245 (Jul. 12, 1996).
Park et al., “Establishment and maintenance of human embryonic stem cells on STO, a permanently growing cell line,” Biol Reprod.;69(6):2007-2014 (Dec. 2003).
Rafii et al., “Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration,” Nat Med.;9(6):702-712 (Jun. 2003).
Shmelkov et al., “Two-dimensional gene expression fingerprinting,” Anal Biochem;290(1):26-35 (Mar 1, 2001).
Simonelli et al., Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: a single-institution study. J Clin Oncol.;21(21):3948-3954 (Nov. 1, 2003).
Vincent et al., Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-alvascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cells. Cancer Res.;65(8):3 185-3 192 (Apr. 15, 2005).
Yin et al., “AC133, a novel marker for human hematopoietic stem and progenitor cells,” Blood;90(12):5002-5012 (Dec. 15, 1997).
Milde Till
Rafii Shahin
Shmelkov Sergey V.
Barnhart Lora E
Cornell Research Foundation Inc.
Wilmer Cutler Pickering Hale and Dorr LLP
LandOfFree
Slitrks as markers for stem and progenitor cells and methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Slitrks as markers for stem and progenitor cells and methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Slitrks as markers for stem and progenitor cells and methods... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4280589