SLIT2 underexpression in metastatic prostate cancer

Details SLIT2 underexpression in metastatic prostate cancer SLIT2 underexpression in metastatic prostate cancer

2011-06-28

2011-06-28

Goddard, Laura B (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100, C435S007230

Reexamination Certificate

active

07968294

ABSTRACT:
This invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, this invention relates to SLIT2 cancer markers that are useful as diagnostic markers and clinical targets for prostate cancer.

REFERENCES:
patent: 2006/0024692 (2006-02-01), Nakamura et al.
Hui et al (Annual Report Prepared for the US Army Medical Research and Material Command, Grant No. W81XWH-04-1-0185, (Feb. 1, 2005), Fort Detrick, MD, p. 4-9 (IDS)).
Dallol et al (Cancer Research, 2002, 62:5874-5880, IDS).
Hui, Xu, et al.; “Enhancement of Tumor Immunotherapy by Blockade of a Prostate Tumor Derived Immunosuppressive Factor;” Grant No. W81XWH-04-1-0185; Annual Report Prepared for the U.S. Army Medical Research and Material Command, (Feb. 1, 2005), Fort Detrick, Maryland; pp. 4-9.
Dallol, Ashraf, et al.; “SLIT2, a Human Homologue of theDrosophilaSlit2 Gene, Has Tumor Suppressor Activity and is Frequently Inactivated in Lung and Breast Cancers”; Cancer Research, (Oct. 15, 2002); vol. 62; (pp. 5874-5880).

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