Sleep-inducing pharmaceutical composition and method

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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424154, 424319, A61K 31195, A61K 3306, A61K 3314

Patent

active

044193459

ABSTRACT:
A highly effective sleep-inducing pharmaceutical composition that causes few, if any, side-effects contains an amino acid and a cation in certain proportions. The amino acid may be tryptophan, cystathionine, or lysine, preferably tryptophan, and most preferably L-tryptophan, and the cation may be calcium, magnesium, manganese, or lithium, preferably calcium or magnesium, and most preferably calcium. The ratio of amino acid to cation is about 0.02:1 to 1.0:1 when the cation is calcium or magnesium, 5:1 to 100:1 when the cation is manganese, and 0.02:1 to 100:1 when the cation is lithium. The pharmaceutical composition may be administered in any conventional manner.

REFERENCES:
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patent: 3847941 (1974-11-01), Brana et al.
patent: 4000297 (1976-12-01), Rovati et al.
patent: 4029807 (1977-06-01), Roldan et al.
patent: 4161530 (1979-07-01), Koella
John A. Oates, M.D. et al., "Neurologic Effects of Tryptophan in Patients Receiving a Monoamine Oxidase Inhibitor", pp. 1076-1078.
Richard J. Wyatt et al., "Effects of L-Tryptophan (A Natural Sedative) on Human Sleep," Oct. 24, 1970, pp. 842-846.
B. J. Key et al., "Neuropharmacological Comparison of Cystathionine, Cysteine, Homoserine and Alpha-Ketobutyric Acid in Cats, 38 1970, pp. 349-357.
J. Hubert Lacey et al., "The Immediate Effect of Intravenous Specific Nutrients on EEG Sleep," 1978, pp. 275-280.
Ernest Hartmann, M.D., "Brief Communication-Sleep Induced by L-Tryptophan," vol. 167, No. 8, pp. 497-499.
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Carlton K. Erickson et al., "Ethanol: Modification of Acute Intoxication by Divalent Cations," Mar. 17, 1978, pp. 1219-1221.
R. Adron Harris, "Alteration of Alcohol Effects by Calcium and Other Inorganic Cations," 1979, pp. 527-534.
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"Cuisine"-The Magazine of Food and Creative Living, May 1979, 2 pp.

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