Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2008-05-06
2008-05-06
Benzion, Gary (Department: 1637)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
Reexamination Certificate
active
07368264
ABSTRACT:
The present invention provides methods for diagnosing or identifying susceptibility of a subject to an anxiety or mood disorder. One method involves testing a sample obtained from the subject for the presence of a polymorphism in Intron 10 of the SLC1A1 gene. The presence of allele G or allele A of the A/G polymorphism rs301434 indicates that the patient is susceptible to an anxiety disorder. An alternate method involves testing a sample obtained from the subject for the presence of a polymorphism in the 3′ untranslated region of the SLC1A1 gene. The presence of allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to an anxiety disorder. Furthermore, a method is provided that involves testing a sample obtained from the subject for the presence of a haplotype in the SLC1A1 gene, wherein the combined presence allele G of the A/G polymorphism rs301434 and allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to a mood disorder.
REFERENCES:
patent: 5210015 (1993-05-01), Gelfand et al.
patent: 5487972 (1996-01-01), Gelfand et al.
patent: WO/95/13399 (1995-05-01), None
Dickelet al. Arch. Gen. Psychiatry, vol. 63, pp. 778-785, Jul. 2006.
S.A. Rasmussen et al., “The Epidemiology and Differential Diagnosis of Obsessive Compulsive Disorder” J. Clin. Psychiatry, vol. 53, 4 suppl., pp. 4-10 (1992).
J. Alsobrook et al., “Segregation Analysis Of Obsessive-Compulsive Disorder Using Symptom-Based Factor Scores”, American Journal of Medical Genetics (Neuropsychiatric Genetics) vol. 88, pp. 669-675 (1999).
R. R. Anholt et al., “Quantitative Genetic Analyses Of Complex Behaviours In Drosophila”, Nature Reviews Genetics, vol. 5, pp. 838-849 (2004).
P. D. Arnold et al., “Association Of A Glutamate (NMDA) Subunit Receptor Gene (GRIN2B) With Obsessive-Compulsive Disorder: A Preliminary Study”, Psychopharmacology (Berl), vol. 174, pp. 530-538 (2004).
P. D. Arnold et al., “Glutamate Transporter Gene SLC 1 A 1 Associated With Obsessive-Compulsive Disorder”, Arch. Gen. Psychiatry, vol. 63 (7), pp. 769-776. (2006).
J. C. Barrett et al., “Haploview: Analysis And Visualization Of LD And Haplotype Maps”, Bioinformatics, vol. 21, Issue 2, pp. 263-265 (2005).
S. Bhattacharyya et al., “A Family Genetic Study Of Clinical Subtypes Of Obsessive-Compulsive Disorder”, Psychiatric Genetics, vol. 15, No. 3, pp. 175-180 (2005).
O. J. Bienvenu et al., “The Relationship Of Obsessive-Compulsive Disorder To Possible Spectrum Disorders: Results From A Family Study”, Biological Psychiatry, vol. 48, pp. 287-293 (2000).
Y. L. Bronstein, et al., “Neurochemistry Of Frontal-Subcortical Circuits”. In: Lichter D, Cummings J, eds. Frontal-subcortical circuits in psychiatric and neurological disorders. New York: Guilford Press, pp. 59-91 (2001).
G. Carey et al., “Twin And Family Studies Of Anxiety, Phobic And Obsessive Disorders”, In: Klein D, Rabkin , J, eds. Anxiety:New Research And Changing Concepts. New York:Raven Press; pp. 117-136 (1981).
M. C. Cavallini et al., “Complex Segregation Analysis For Obsessive Compulsive Disorder And Related Disorders”, American Journal of Medical Genetics (Neuropsychiatric Genetics) vol. 88, pp. 38-43 (1999).
N. Chabane et al., “Early-Onset Obsessive-Compulsive Disorder: A Subgroup With A Specific Clinical And Familial Pattern?”, Journal of Child Psychology Psychiatry; vol. 46, No. 8, pp. 881-887 (2005).
B. Conne et al., “The 3′ Untranslated Region Of Messenger RNA: A Molecular 'Hotspot' For Pathology?”, Nature Medicine, vol. 6, No. 6, pp. 637-641 (2000).
R. Delorme et al., “Frequency And Transmission Of Glutamate Receptors GRIK2 And GRIK3 Polymorphisms In Patients With Obsessive Compulsive Disorder”, Clinical Neuroscience and Neuropathology, vol. 15, No. 4, pp. 699-702 (2004).
D. Denys et al., “Symptom Dimensions In Obsessive-Compulsive Disorder: Factor Analysis On A Clinician-Rated Scale And A Self-Report Measure”, Psychopathology vol. 37, pp. 181-189 (2003).
M. B. First et al., “Structured Clinical Interview for DSMIV Axis I Disorders”, Patient Edition. (SCID-I, version 2.0). New York: Biometrics Research Department , New York State Psychiatric Institute (1996).
W. K. Goodman et al., “The Yale-Brown Obsessive Compulsive Scale: I. Development, use, and reliability”, Arch Gen Psychiatry, vol. 46, pp. 1006-1011 (1989).
W. K. Goodman et al., The Yale-Brown Obsessive Compullsive Scale (Y-BOCS), Arch Gen Psychiatry, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. (vol. 46:1006-1011) Washington, DC American Psychiatric Association, 1994), SCID (Structured Clinical Interview for DSM-IV), or FIGS (Family Interview for Genetic Studies, (1989).
I. I. Gottesman, et al., “The Endophenotype Concept In Psychiatry: Etymology And Strategic Intentions”, American Journal of Psychiatry; vol. 160, pp. 636-645 (2003).
G. L. Hanna et al., “Familial And Sporadic Subtypes Of Early-Onset Obsessive-Compulsive Disorder”, Biological Psychiatry, vol. 57, pp. 895-900 (2005).
J. M. Hettema et al., “A Review And Meta-Analysis Of The Genetic Epidemiology Of Anxiety Disorders”. American Journal of Psychiatry; vol. 158, pp. 1568-1578 (2001).
G. L. Hanna et al., Genome-Wide Linkage Analysis Of Families With Obsessive-Commpulsive Disorder Ascertained Through Pediatric Probands, American Journal of Medical Genetics (Neuropsychiatric Genetics) vol. 114, pp. 541-552 (2002).
D. Hien et al., “Structured interview for DSM-IV childhood diagnoses (KID SCID)”, Unpublished manuscript (1999).
Y. H. Huang et al., “Glutamate Transporters Bring Competition To The Synapse”, Current Opinion in Neurobiology, vol. 14, pp. 346-352 (2004).
Inouye E., “Similar And Dissimilar Manifestations Of Obsessive-Compulsive Neurosis In Monozygotic Twins”, American Journal of Psychiatry, vol. 121, pp. 1171-1175 (1965).
International HapMap Consorium, “The International HapMap Project”, Nature, vol. 426, pp. 789-796 (2003).
Y. Kanai et al., “The Glutamate/Neutral Amino Acid Transporter Family SLC 1: Molecular, Physiological And Pharmacological Aspects”, . Pflugers Arch—Eur J. Physiol., vol. 447, pp. 469-479 (2004).
D. Lahiri et al., “A Rapid Non-Enzymatic Method For The Preparation Of HMW DNA From Blood For RFLP Studies”, . Nucleic Acids Resesearch, vol. 19, pp. 5444 (1991).
N. Laird et al., “Implementing A Unified Approach To Family Based Tests Of Association”, Genetic Epidemiology, vol. 19 (Suppl 1) pp. S36-S42 (2000).
M. B. Lanktree et al., “PedSplit: Pedigree Management For Stratified Analysis”, Bioinformatics, vol. 20 No. 14, pp. 2315-2316 (2004).
J. F. Leckman et al., “Symptoms Of Obsessive-Compulsive Disorder”, American Journal of Psychiatry, vol. 154 (7) pp. 911-917 (1997).
J. F. Leckman et al., “Obsessive-Compulsive Symptom Dimensions In Affected Sibling Pairs Diagnosed With Gilles De La Tourette Syndrome”, . American Journal of Medical Genetics (Neuropsychiatric Genetics) vol. 116B, pp. 60-68 (2003).
D. Mataix-Cols et al., “A Multidimensional Model Of Obsessive-Compulsive Disorder”, American Journal of Psychiatry, vol. 162 (2) pp. 228-238 (2005).
G.C. Mathews et al., “Neuronal Glutamate Uptake Contributes To GABA Synthesis And Inhibitory Synaptic Strength”, Journal of Neuroscience, vol. 23 (6) pp. 2040-2048 (2003).
E.C. Miguel et al., “Obsessive-Compulsive Disorder Phenotypes: Implications For Genetic Studies”. Molecular Psychiatry, vol. 10, pp. 258-275 (2005).
C. Murray et al., “Global Burden Of Disease: A comprehensive assessment of mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020”. vol. 1, Harvard: World Health Organization (1996).
G. Nestad
Arnold Paul Daniel
Kennedy James Lowery
Richter Margaret A.
Benzion Gary
Centre for Addiction and Mental Health
Wilder Cynthia B
Winston & Strawn LLP
LandOfFree
SLC1A1 marker for anxiety disorder does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with SLC1A1 marker for anxiety disorder, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and SLC1A1 marker for anxiety disorder will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2771174