Skin-whitening agent

Details Skin-whitening agent Skin-whitening agent

1998-04-14

1999-11-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 62, A61K 600, A61K 700, A61K 3322, A01N 5914

Patent

active

059938358

ABSTRACT:
Disclosed is a skin-whitening agent which comprises as its effective ingredient a group of substances capable of forming chemical complexes with melanin monomers. Boron-containing compounds and organelles originated from animals, plants and microorganisms make the invention feasible as they commonly suppress pigmentation through a novel action mechanism where melanin monomers are trapped by chemical complex formation.

REFERENCES:
patent: 5116980 (1992-05-01), Gabel
patent: 5587173 (1996-12-01), Junino et al.
Inhibitory Effects of Melanin Monomers, Dihydroxyindole-2-Carboxylic Acid (DHICA) and Dihydroxyindole (DHI) On Mammalian Tyrosinase, With a Special Reference to the Role of DHICA/DHI Ratio in Melanogenesis.
Mishima A. et al., "Regulatory Factors For Polymerization Of Melanin Monomers Within Coated Vesicles And Premelanosomes In Melanoma Cells," Melanoma Research, 3:255-262 (1993).
Abstract of Mishima et al., "Overview of Research and Development of New Third-Generation Skin-Lighting Agents." Fragrance J., 26-1:34-44 (1998).

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