Skin whitener composition containing mercaptodextran

Drug – bio-affecting and body treating compositions – Bleach for live hair or skin

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424 59, 514844, A61K 748, A61K 740

Patent

active

060775033

ABSTRACT:
A skin whitening composition includes mercaptodextran. The composition can be topically applied to the human skin and can include one or more whitening agents in combination with mercaptodextran to achieve enhanced whitening effect. A method of whitening human skin includes topically applying to the skin mercaptodextran in an amount and for a period of time sufficient to visibly whiten the skin. The method includes incorporating mercaptodextran with known whitening agents and applying to the skin in an amount and for a period of time sufficient to visibly whiten the skin.

REFERENCES:
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patent: 5527509 (1996-06-01), Gibson
patent: 5683705 (1997-11-01), Maes et al.
patent: 5710177 (1998-01-01), Sauermann et al.
Chemical Abstract No. 79062906; CA 79(11)62906q; Mercaptodextran, a metal-chelating and disulfide-reducing polythiol of high molecular weight; Author(s): Jellum, Egil; Aaseth, Jan; Eldjarn, Lorentz; Location: Rikshosp., Oslo, Norway; Journal: Biochem. Pharmacol.; Date: 1973; vol. 22; No. 10; pp. 1179-1188.
Mercaptodextran--a new copper chelator and scavenger of oxygen radicals; Aaseth, Jan; Benov, Ludmil; Ribarov, Stefan; Acta Pharmacologica Sinica; 1990; Jul.; 11(4): 363-367.
The Effect of Mercaptodextran and N-Acetylhomo-Cysteine on the Excretion of Mercury in Mice Exposed to Methyl Mercuric Chloride, J. Aaseth; T. Norseth; Commission of the European Communities, U.S. Environmental Protection Agency, World Health Organization, International Symposium Proceedings, Recent Advances in the Assessment of the Health Effects of Environmental Pollution; vol. II, Paris, Jun. 24 to 28, 1974; pp. 913-919.
The Effect of Mercaptodextran and N-Acetylhomocysteine on the Excretion of Mercury in Mice After Exposure to Methyl Mercury Chloride; Aaseth, Jan; Norseth, Tor; Journal: Acta Pharmacol Toxicol; vol. 35(1); pp. 23-32; Year: 1974.
The Effect of Mercaptodextran on Distribution and Toxicity of Mercury in Mice; Aaseth, Jan; Journal: Acta Pharmacol Toxicol; vol: 32(6): pp. 430-441; Year: 1973

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