Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1997-06-18
1998-09-15
Naff, David M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
435325, 435357, 435371, 435390, 435404, 514 23, 514474, 514844, 548535, 562562, A61K 3578, A61K 3170, A61K 31375, C12N 500
Patent
active
058075550
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
The present invention essentially relates to a cosmetic or pharmaceutical and particularly dermatological composition, and a culture medium containing a Smelophyllum capense extract.
More specifically, the present invention relates to the use of a Smelophyllum capense extract, for preparing a cosmetic or pharmaceutical and particularly dermatological composition, which particularly promotes collagen synthesis, and which is intended in particular for controlling the effects of skin ageing, for obtaining a skin firming, for improving healing or for treating the various pathologies accompanied with a deficiency of collagen; or as one of the active principles or additives for a cell or tissue culture medium, especially for the mass culture of skin cells, in particular fibroblasts, as well as cosmetic or pharmaceutical compositions or culture media comprising application thereof.
The Smelophyllum capense plant belongs to the Sapindaceae family which groups about 1,700 plant species. The plants of this family contain saponines which have been used for a long time as a detergent and as fish poison.
The Smelophyllum capense plant is a tree of relatively modest height, it being from 3 to 4 meters tall, that is found in the endemic state particularly in the forests of the southern part of South Africa (see R. B. Drumont, "Trees of Southern Africa, C. Struik Publisher, Capetown, 1984, page 531).
It has now been discovered that Smelophyllum capense extracts have a large interest in cosmetics, particularly for skin care.
In particular, a surprising activity of the Smelophyllum capense extracts has been discovered on the synthesis of collagen, in particular of type I collagen, hereinafter referred to as the abbreviation "collagen I". Now the skin essentially contains collagen I, a protein synthesised by the fibroblasts which are the major cells of the dermis. This protein plays a support role and is responsible for the rheological qualities of the dermis, in particular, it is responsible for its firmness and for the upkeep of its structure (E. U. KUCHARZ, "The collagens: Biochemistry and pathophysiology", Springer Verlag, Berlin 1992). Furthermore, it has been demonstrated that the fibroblasts of the dermis of elderly people secrete less collagen than those of young subjects (M. DUMAS et al, Mech, Ageing Dev. (1994) 73, 179-187). Thus, with age, a decrease of the rheological qualities, and a decrease in its response to constraints to which it is submitted very day is produced. The skin stretches, reacts less well to tensions, looses its tonus and wrinkles form.
From this, the action of Smelophyllum capense extracts upon the synthesis of collagen renders the extracts particularly useful for controlling the effects of skin ageing, such as wrinkles or the slackening of the tissues of the skin support, or for improving healing.
SUMMARY OF THE INVENTION
The principal aim of the present invention is to solve the new technical problem consisting of providing a novel formulation of a cosmetic or pharmaceutical and particularly dermatological composition which has a good effectiveness upon the prevention or the treatment of the effects of skin ageing, as well as upon the skin firming, or for improving healing.
Another principal aim of the present invention is to solve this novel technical problem in a particularly simple and satisfactory way which is useable on an industrial scale, particularly in the cosmetic or pharmaceutical industry.
Thus, according to a first aspect, the present invention relates to the use of a Smelophyllum capense extract as cosmetic agent, particularly for care of the skin.
DETAILED DESCRIPTION OF THE INVENTION
According to an embodiment variant of the invention, a Smelophyllum capense extract is used for preparing a cosmetic or pharmaceutical and particularly dermatological composition which particularly promotes collagen synthesis, in particular that of collagen I, and particularly intended for improving skin healing, for improving the biomechanical and the appearance
REFERENCES:
Lavaud et al. Bull. Societe Royale des Sciences de Liege, vol. 63, pp. 455-463, 1994.
Bonte Frederic
Dumas Marc
Lavaud Catherine
Massiot Georges
Kerr Janet M.
LVMH Recherche
Naff David M.
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