Skin treatment with salicylic acid esters and retinoids

Details Skin treatment with salicylic acid esters and retinoids Skin treatment with salicylic acid esters and retinoids

1996-11-27

1998-03-17

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514546, 514549, 514725, A61K 742

Patent

active

057287325

ABSTRACT:
A method and composition is provided for treating skin conditions including those arising from dermatologic disorders, chronoaging and environmental abuse. Non-ring esterified C.sub.11 -C.sub.30 alkyl or alkenyl esters of salicylic acid in combination with a retinol C.sub.18 -C.sub.30 fatty acid ester used as the active components are applied to the skin in a pharmaceutically acceptable carrier. Most preferred as the salicylate ester is tridecyl salicylate and as the retinol fatty acid ester is retinyl linoleate.

REFERENCES:
patent: 4603146 (1986-07-01), Kligman
patent: 4877805 (1989-10-01), Kligman
patent: 4891227 (1990-01-01), Thaman et al.
patent: 4891228 (1990-01-01), Thaman et al.
patent: 5262407 (1993-11-01), Leveque et al.
Product Brochure--Vevy Europe, BTNA (1991).
Product Brochure--Lexicon Vevy Europe, Skin Care Instant Reports (1990).
Elizabeth Arden "SPA Comeback Cream"--(1994) carton with ingredient listing including tridecyl salicylate.
Kang et al Journal of Investigative Dermatology, Inc., pp. 359-556 (1995) "Application of Retinol to Human Skin In Vivo Induces Epidermal Hyperplasia and Cellular Retinoid Binding Proteins Characteristic of Retinoic Acid but Without Measurable Retinoic Acid Levels or Irritation".

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