Skin test for schizophrenia

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Reexamination Certificate

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C424S009800, C435S007200, C435S007210, C435S007240, C436S811000

Reexamination Certificate

active

07070760

ABSTRACT:
A diagnostic method for assaying schizophrenia in a subject is provided wherein a preparation comprising platelet derived proteins or fractions thereof having a pI above about 6.5 is injected into a subject and the occurrence of delayed type hypersensitivity (DTH) reaction at the site of the injection is determined. A positive DTH reaction indicates that the tested subject has a high likelihood of being schizophrenic. The protein preparation used in the diagnostic method is also provided as well as a method for its preparation and a kit for use in the diagnosis of schizophrenia using the above method.

REFERENCES:
patent: 5429947 (1995-07-01), Merril et al.
patent: 97/13152 (1997-04-01), None
Kessler et al., Number of Platelet Dense Granules Varies with Age, Schizophrenia, and Dementia, Nov.-Dec. 1995, Demenita 6(6): 330-3.
Stryer et al, in Biochemistry, Third edition, W H Freeman Company, New York, pp. 31-33, 1998.
Jankovic et al, J Immunol 135(2 suppl): 583s-587s, Aug. 1985.
Ovary et al, Adv Biol Skin 11: 103-21, 1971.
Deckmann et al, Ital. J Psych Behav Sci 6: 29-34, 1996.
“The Arthus Reaction and Delayed Hypersensitivity Reaction To Neurospecific Proteins s-100 and 10-40-4 In Schizophrinic Patients”,Biological Abstracts, Abstract No. 24088, XP-002100216.

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