Skin substitutes and uses thereof

Details Skin substitutes and uses thereof Skin substitutes and uses thereof

2005-01-25

2005-01-25

Lankford, Jr., Leon B. (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

C435S373000, C435S382000, C435S393000, C424S093700

Reexamination Certificate

active

06846675

ABSTRACT:
The present invention relates to in vitro cultured skin substitutes, and in particular to improved methods for organotypic culture of skin substitutes. In some embodiments, the dermal equivalent of the skin substitute is lifted to air interface of the culture prior to seeding with keratinocytes. In other embodiments, increased concentrations of collagen are used to form the dermal equivalent. In still other embodiments, optimized media are utilized to maintain the skin equivalents.

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