Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1995-06-06
1997-09-16
Low, Christopher S. F.
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
4352402, 43524021, 435 701, 43524023, 623 15, 424 7806, 424 931, 606132, 606133, A01N 102, C12N 506
Patent
active
056679610
ABSTRACT:
The invention concerns a skin substitute composed of a dermis equivalent covered with an epidermis equivalent. The dermis equivalent is a film formed from a type I collagen gel containing fibroblasts. The epidermis equivalent incorporates a basal membrane equivalent, basal layer cells, in a palisade arrangement attached to the membrane equivalent by hemidesmosomes, cells of the suprabasal layers, granular cells, and flat, keratinized cells arranged near the free surface.
REFERENCES:
patent: 4485096 (1984-11-01), Bell
patent: 4604346 (1986-08-01), Bell
G. Shaumburg-Lever et al, "Ultrastructural Localization of in vivo bound Immunoglobulins in bullous pemphigold--a Preliminary Report", J. Invest. Dermatol. G4:47-49, 1975.
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J. Stanley et al., "The Epidermal Cell which Selectively Adheres to A Collagen Substrate the Basal Cell," J. Invest. Dermatol. 74:54-58, 1980.
J. Stanley et al, "Characterization of Bullous Pemphigold Antigen: a Unique Basement Membrane Protein of Stratified Squamous Epithella," Cell 24:897-903, 1981.
J. Stanley et al, "Structure and Function of Basement Membrane," J. Invest. Dermatol. 79:69s-72s, 1982 (includes Figure 1).
D. F. Mutasim et al, "A Pool of Bullous Pemphigoid Antigen(s) Is Intracellular and Associated with the Basal Cell Cytoskeleton-Hemidesmosome Complex," J. Invest. Dermatol. 84:47-53 1985.
Vermorken 1985, Atla 13, 8-37.
Limat et al 1986 J. Invest. Dermatol. 87, 485-488.
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Asselineau Daniel
Bernard Bruno
Darmon Yves-Michel
Lenoir Marie-Cecile
Shroot Braham
Centre International De Recherches Dermatologigues Galderma (Cir
Low Christopher S. F.
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