Skin replication technique

Details Skin replication technique Skin replication technique

1990-10-09

1993-05-18

Woo, Jay H.

Plastic and nonmetallic article shaping or treating: processes

With measuring, testing, or inspecting

264222, 264225, 264226, 264DIG30, 425 2, 523109, B29C 3340, B29C 3902

Patent

active

052118940

ABSTRACT:
The invention provides a composition and a method for studying skin surface areas with simplified magnifying devices by making a replication of the skin surface area while minimizing irritation to the subject's skin, cracking of the replicas, surface artifacts, and air bubbles in the replicas. The method entails preparing a negative skin surface replica composition by mixing a silicone polysiloxane base and a biocompatible surface tension modifying agent. The mixture is placed in a vacuum desiccator to remove air bubbles and thereafter a curing agent is added to the mixture. An adhesive collar is placed on the subject's skin, which collar surrounds the surface area to be replicated, and thereafter the composition is applied to the skin surface area and the adhesive collar and allowed to dry. The negative skin surface casting is removed from the skin area and is then placed skin side up in a mold cup. A positive liquid skin surface replica composition comprising a polyethylene, a polyethylene copolymer and a low micron pigment blend is prepared and is heated. The positive replica composition is then poured into the mold cup until the negative casting is covered. The mold cup is centrifuged, cooled to room temperature and thereafter the negative and positive skin surface replica castings are separated and studied.

REFERENCES:
patent: 3082527 (1963-03-01), Nitsche et al.
patent: 3261802 (1966-07-01), Bobear
patent: 3696090 (1972-10-01), Lampe
patent: 3989790 (1976-11-01), Bruner et al.
patent: 4007153 (1977-02-01), Smith
patent: 4071507 (1978-01-01), Schoen
patent: 4116914 (1978-09-01), Coran et al.
patent: 4144206 (1979-03-01), Symeon
patent: 4199825 (1980-04-01), Knoche
patent: 4223122 (1980-09-01), Cella
patent: 4302571 (1981-11-01), Arai et al.
patent: 4341888 (1982-07-01), Razzano
patent: 4389496 (1983-06-01), Leusner et al.
patent: 4421769 (1983-12-01), Dixon et al.
patent: 4559189 (1985-12-01), Wegener, II
patent: 4568707 (1986-02-01), Voigt et al.
patent: 4581347 (1986-04-01), Kumagai et al.
patent: 4609545 (1986-09-01), Schlossman
patent: 4619848 (1986-10-01), Knight et al.
patent: 4623693 (1986-11-01), Inoue et al.
patent: 4657959 (1987-04-01), Bryan et al.
patent: 4778832 (1988-10-01), Futami et al.
patent: 4832978 (1989-05-01), Lesser
patent: 4837274 (1989-06-01), Kawakubo et al.
patent: 4882162 (1989-11-01), Ikada et al.
Makki et al, "A Quantitative Method for the Assessment of the Microtopography of Human Skin" Acta Dermatovener (Stockholm) (1979) pp. 285-291.
Barbenel et al. "The Variability of Skin Surface Contours" Annals of Biomedical Engineering, vol. 8, (1980), pp. 175-182.
Mignot et al. "Microtopographical Analysis of Human Skin Surface" Bioeng Skin (1985) pp. 101-110.
Joan Sampson "A Method of Replicating Dry or Moist Surfaces for Examination by Light Microscopy" (Aug. 1961), pp. 932-933, Nature.
Goldman et al. "Replica Microscopy and Scanning Electron Microscopy of Laser Impacts on the Skin" (1969), pp. 18-23, vol. 52, No. 1. J. Inv. Derm.
Bernstein and Jones "Skin Replication Procedure for the Scanning Electron Microscope" Science (1969), pp. 166, 253.
Kairnen and Kaszynski "Scanning electron microscopy of skin replicas showing demodectic infestation of the pilosebaceous follicle" Journal of Cutaneous Pathology (1984), pp. 103-106, vol. 11.
Kuokkanen "Replica Reflection of Normal Skin and of Skin with Disturbed Keratinization" Acta Dermatovener (Stockholm) (1972) pp. 52:205-210.
Barnes "Techniques for the replication of skin surfaces" British Journal of Dermatology (1973), pp. 277-283.
Garber and Nightingale "Characterizing Cosmetic Effects and Skin Morphology by Scanning Electron Microscopy" J. Soc. Cosmet. Chem. (1976), pp. 509-531.
Pameijer "Replication Techniques with New Dental Impression Materials in Combination with Different Negative Impression Materials" Scanning Electron Microscopy (1979), pp. 571-574.
Ryan et al. "A replica technique for the evaluation of human skin by scanning electron microscopy" Journal of Cutaneous Pathology (1983), pp. 262-276.

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