Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1996-09-20
1998-12-08
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424447, 424449, A61F 1302
Patent
active
058465596
ABSTRACT:
A skin patch is disclosed for usage in the delivery of a contactant to human skin for the purpose of treating medical conditions responsive to contact immunotherapy. The skin patch specifically induces a cell-mediated contact dermatitis in the treatment of skin disorders. Its anticipated use pertains to treatment of human papilloma virus infections, or warts. In a first embodiment, a pressure activated single chambered skin patch is topically applied and used for controlled release of contactant to human skin. In a second embodiment, a pressure activated two chambered skin patch is topically applied and used for controlled release of a contactant to human skin. Alternatively, a single chambered skin patch is topically applied and hydrated by the contacted skin for release of contactant. In addition, a flared shroud region can be provided between the containment portion of the shroud and a surrounding adhesive flange to enlarge the area treated upon release of the contactant. The contactants include dinitrochlorobenzene, diphenylcyclopropenone, squaric acid dibutyl ester, and their derivatives.
REFERENCES:
patent: 5188509 (1993-02-01), Amkraut
patent: 5273755 (1993-12-01), Venkatrama
Orecchia, G., et al., "Treatment of multiple relapsing warts with diphenciprone", Dermatologica, vol. 177 No. 4, 225-231(1988).
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Sanders, Beverly B., et al., "Dinitrochlorobenzene immunotherapy of human warts", CUTIS, vol. 27, 389-392 (1981).
Naylor, Mark F., et al, "Contact immunotherapy of resistant warts", Journal of the America Academy of Dermatology, vol. 19, No. 4, Oct. 1988.
Lee, Sungnack, et al., "Therapeutic effect of dinitrochlorobenzene (DNCB) on verruca plana and verruca vulgaris", International Journal of Dermatology vol. 29, No. 9, Nov. 1984.
Dunagin, W.G., et al., "Dinitrochlorobenzene immunotherapy for verrucae resistant to standard treatment modalities", Journal of the American Academy of Dermatology, vol. 6, No. 1, Jan. 1982.
Ericksen, Knud., "Treatment of the common wart by induced allergic inflammation", Dermatologica, vol. 160, 161-166 (1980).
Greenburg, Joseph H., et al. "Verrucae vulgaris rejection", Arch Dermatol, vol. 107, 580-582, Apr. 1973.
Buckner, Dorothy, et al, "Immunotherapy of verrucae vulgares with dinitrochlorobenzene", British Journal of Deramtology, vol. 98, 451-455 (1978).
Lewis, Henry, "Topical immunotherapy of refractory warts", CUTIS, vol. 12, 863-867, Dec. 1973.
May Stephen R.
Phelan D. Gabrielle
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