Skin model system

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell

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623 1, 623 11, 623 12, 623 13, 623 66, 4352401, 4352402, 43524023, 43524024, 43524021, 43524043, 424574, A61K 3536

Patent

active

059451017

ABSTRACT:
This invention relates to a skin model system that can be used as an in vitro test system or which can be used for therapeutic purposes. The skin model system comprises a three-dimensional, cross-linked matrix of insoluble collagen containing fibroblast cells therein, and stratified layers of differentiated epidermal cells supported thereon.

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patent: 5282859 (1994-02-01), Eisenberg
Bell et al., "The Reconstitution of Living Skin", J. Invest. Dermatology, 1983, 81, 2s-10s.
Doillon et al., "Behavior of fibroblasts and epidermal cells cultivated on analogues of extracellular matrix", Biomaterials, 1988, 9, 91-96.
Dykes et al., "In Vitro Reconstruction of Human Skin: The Use of Skin Equivalents as Potential Indicators of Cutaneous Toxicity", Toxic. In Vitro, 1991, 5, 1-8.
Leighton et al., "Patterns of Three-dimensional Growth in Vitro in Collagen-coated Cellulose Sponge: Carcinomas and Embryonic Tissues", Cancer Res., 1968, 28, 286-296.

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