Skin lightening agents, compositions and methods

Details Skin lightening agents, compositions and methods Skin lightening agents, compositions and methods

2007-11-27

2007-11-27

Dodson, Shelley A. (Department: 1616)

Drug, bio-affecting and body treating compositions

Bleach for live hair or skin

C424S059000, C424S060000, C424S400000, C424S401000, C514S543000, C514S544000

Reexamination Certificate

active

10789293

ABSTRACT:
Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle:Where each or both R1and/or R2represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; andR3represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; andR4represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2and R4represent H, while R3represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture.Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

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