Skin external agents and drugs

Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Skin cosmetic coating

Reexamination Certificate

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C424S401000, C424S078020

Reexamination Certificate

active

07037489

ABSTRACT:
Skin external agent compositions and drugs characterized by containing fumaric acid diester derivatives represented by following general formula (1), wherein R1represents C1-4alkylene; R2and R3represent each liner or branched C1-8alkyl; and n is an integer of 2 to 5; which provide epidermal barrier function potentiating agents and skin external agent compositions having a high safety, quickly relieving epidermal permeation barrier function failures and having an effect of maintaining the skin in a cosmetologically healthy state; agents to be used together with HB-EFG expression inducing agents accelerating epidermal turnover, amphiregulin expression inhibitors regulating excessive epidermal proliferation, and retinoic acid or its derivative preventing skin chapping caused by retinoic acid or its derivative; and skin aging relieving agents capable of ameliorating depression in the skin metabolism and thinning in association with aging.

REFERENCES:
patent: 5451667 (1995-09-01), Speiser et al.
patent: 5837728 (1998-11-01), Purcell
patent: 2924042 (1980-02-01), None
patent: 04-018017 (1992-01-01), None
patent: 09-255622 (1997-09-01), None
patent: 09255622 (1997-09-01), None
Arroyo et al, Revista de Plasticos Modernos, 1073, 26(208), 574-80.

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