Skin equivalent comprising langerhans' cells

Details Skin equivalent comprising langerhans' cells Skin equivalent comprising langerhans' cells

1997-01-23

1999-01-19

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C12N 508, C12N 506

Patent

active

058611533

ABSTRACT:
The present invention relates to a reconstructed skin model, characterized in that it comprises an epidermis equivalent on a support, the said epidermis equivalent comprising at least keratinocytes and at least induced or noninduced precursors of Langerhans' cells, as well as the process for preparing the said skin equivalent.
The invention also relates to an epidermis equivalent, characterized in that it comprises at least keratinocytes and at least induced or noninduced precursors of Langerhans' cells and to the process for preparing it.

REFERENCES:
Prignano et al., Molecular Biology of the Cell 7 (SUPPLE.) 142A 1996.
Koch et al., J Exp Med 171(1): 159-172 (1990).
Witmer-Pack et al., J Exp Med 166(5): 1484-1498 (1987).
Heufler et al., J Exp Med 167(2): 700-705 (1988).
Czernielewski et al., Arch Dermatol Res 276(5): 288-292 (1984).

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