Skin care compositions containing dimethyl imidazolidinone and r

Details Skin care compositions containing dimethyl imidazolidinone and r Skin care compositions containing dimethyl imidazolidinone and r

1995-06-01

1996-07-16

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514529, 514549, 514725, A61K 31415, A61K 31215, A61K 3107

Patent

active

055367402

ABSTRACT:
Dimethyl imidazolidinone in combination with either retinol or retinyl ester resulted in a synergistic enhancement in keratinocyte proliferation and synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in combination with dimethyl imidazolidinone were analogous to treatment with retinoic acid.

REFERENCES:
patent: 4216201 (1980-08-01), Calvo
patent: 4900550 (1990-02-01), Lowry
patent: 5124320 (1992-06-01), Ivy et al.
Vahlquist A. et al., "Isotretinoin Treatment of Severe Acne Affects the Endogenous Concentration of Vitamin A in Sebaceous Glands", J. Invest. Dermatol., vol. 94, (1990), pp. 496-498.
Ellis, C. N. et al., "Treatment of Actinically Aged Skin with Topical Tretinoin", Pharmacology of Retinols in Skin, vol. 3, (1989), pp. 249-252.
Lowe, N. J. et al., "Systemic Reinoids in Psoriasis: Comparative Efficacy and Toxicity", Pharmacology of Retinols in Skin, vol. 3, (1989), pp. 240-248.

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