Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Statutory Invention Registration
1997-05-23
2002-08-06
Jordan, Charles T. (Department: 3641)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S549000
Statutory Invention Registration
active
H0002043
ABSTRACT:
TECHNICAL FIELD
Invention relates to skin care compositions containing retinoids which generally improve the quality of the skin, particularly human facial skin. More particularly, the present invention relates to retinol containing skin care compositions with improved skin compatibility.
BACKGROUND OF THE INVENTION
Many personal care products currently available to consumers are directed primarily to improving the health and/or physical appearance of the skin. Among these skin care products, many are directed to delaying, minimizing or even eliminating skin wrinkling and other histological changes typically associated with the aging of skin or environmental damage to human skin.
Skin is subject to insults by many extrinsic and intrinsic factors. Extrinsic factors include ultraviolet radiation (e.g., from sun exposure), environmental pollution, wind, heat, low humidity, harsh surfactants, abrasives, and the like. Intrinsic factors include chronological aging and other biochemical changes from within the skin. Whether extrinsic or intrinsic, these factors result in visible signs of skin aging and environmental damage, such as wrinkling and other forms of roughness (including increased pore size, flaking and skin lines), and other histological changes associated with skin aging or damage. To many people, skin wrinkles are a reminder of the disappearance of youth. As a result, the elimination of wrinkles has become a booming business in youth-conscious societies. Treatments range from cosmetic creams and moisturizers to various forms of cosmetic surgery.
Extrinsic or intrinsic factors may result in the thinning and general degradation of the skin. For example, as the skin naturally ages, there is a reduction in the cells and blood vessels that supply the skin. There is also a flattening of the dermal-epidermal junction which results in weaker mechanical resistance of this junction. See, for example, Oikarinen, “The Aging of Skin: Chronoaging Versus
Photoaging,”
Photodermatol. Photoimmunol. Photomed.,
vol. 7, pp. 3-4, 1990, which is incorporated by reference herein in its entirety.
Retinoids are well recognized as anti-wrinkle actives which help to reduce the subcutaneous effects of aging as wrinkling, leatheriness, looseness, roughness, dryness, and mottling (hyper pigmentation) (see, U.S. Pat. Nos. 4,603,146 and 4,877,805 to Kligman). It has been postulated that retinoids act by producing inflammation, which causes thickening of the epidermis (acanthosis), and local intercellular edema, leading to exfoliation.
In formulating products containing retinoids, much attention is directed toward providing compositions which deliver and retain optimal concentrations of the retinoid in the stratum corneum with minimum absorption into the systemic circulation. Furthermore, promoting user compliance with respect to chronic treatment regimens is also important. Current retinoid formulations, however, can be drying and irritating and result in excessive peeling. Such formulations may cause individuals to refrain from using retinoid products as frequently and copiously as is necessary for optimum benefit.
The present inventors have found that compositions containing natural or synthetic retinoid compounds along with a preservative component comprising a formaldehyde donating preservative and a halopropynyl compound, deliver the skin regulating benefits of retinoid compounds with reduced dryness and/or irritation. These compositions have improved user acceptance and, thus, promote better user compliance with a concomitant overall improvement in skin regulating benefit.
It is, therefore, an object of the present invention is to provide retinoid containing skin care compositions having improved skin compatibility.
Another object of the present invention is to provide retinoid compositions containing preservative systems which provide preservation activity at relatively low concentrations.
Still another object of the present invention is to provide retinoid compositions containing preservative systems which do not substantially impact retinoid stability or bioavailability.
These and other objects of this invention will become apparent in light of the following disclosure.
SUMMARY OF THE INVENTION
The present invention relates to skin care compositions, comprising:
a.) a retinoid; and
b.) a preservative component, comprising:
i.) a formaldehyde donor; and
ii.) a halopropynyl compound selected from the group consisting of iodopropargyl esters, ethers, acetals, carbamates and carbonates.
The present invention further relates to methods of regulating skin conditioning.
DETAILED DESCRIPTION OF THE INVENTION
All percentages and ratios used herein are by weight of the total composition and all measurements made are at 25° C, unless otherwise designated.
The compositions of the present invention can comprise, consist essentially of, or consist of, the essential as well as optional ingredients and components described herein. As used herein, “consisting essentially of” means that the composition or component may include additional ingredients, but only if the additional ingredients do not materially alter the basic and novel characteristics of the claimed compositions or methods.
All publications cited herein are hereby incorporated by reference in their entirety.
The term “topical application”, as used herein, means to apply or spread the compositions of the present invention onto the surface of the skin.
The term “dermatologically-acceptable,” as used herein, means that the compositions or components thereof so described are suitable for use in contact with human skin without undue toxicity, incompatibility, instability, allergic response, and the like.
The term “safe and effective amount” as used herein means an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive skin appearance or feel benefit, including independently the benefits disclosed herein, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
The term “skin compatibility,” as used herein means the ability of skin to tolerate long term application of topical compositions with minimal adverse skin reactions such as stinging, burning, redness, itching and folliculitis.
The compositions of the present invention are useful for topical application and for regulating skin condition, including visible and/or tactile discontinuities in skin (especially the skin surface; such discontinuities are generally undesirable). Such discontinuities may be induced or caused by internal and/or external factors, and include the signs of skin aging described herein. The term “regulating skin condition” includes prophylactically regulating and/or therapeutically regulating skin condition, including visible and/or tactile discontinuities in skin. As used herein, prophylactically regulating skin condition includes delaying, minimizing and/or preventing visible and/or tactile discontinuities in skin. As used herein, therapeutically regulating skin condition includes ameliorating, e.g., diminishing, minimizing and/or effacing, discontinuities in skin. Regulating skin condition involves improving skin appearance and/or feel.
The compositions of the present invention are useful for regulating signs of skin aging, more especially visible and/or tactile discontinuities in skin texture associated with aging. “Regulating the signs of skin aging” includes prophylactically regulating and/or therapeutically regulating one or more of such signs (similarly, regulating a given sign of skin aging, e.g., lines, wrinkles or pores, includes prophylactically regulating and/or therapeutically regulating that sign). As used herein, prophylactically regulating such signs includes delaying, minimizing and/or preventing signs of skin aging. As used herein, therapeutically regulating such signs includes ameliorating, e.g., diminishing, minimizing and/or effacing signs of skin aging.
“Signs of skin aging” include, but are not l
Deckner George Endel
SaNogueira, Jr. James Pedrosa
Zukowski Joseph Michael
Allen George W.
Baker Aileen J.
Jordan Charles T.
Little Darryl C.
LandOfFree
Skin care compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Skin care compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Skin care compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2968674