Skin care composition

Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Skin cosmetic coating

Reexamination Certificate

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C424S400000, C424S401000, C424S489000, C424S059000, C514S844000, C514S845000, C514S846000, C514S847000, C514S848000

Reexamination Certificate

active

06287553

ABSTRACT:

FIELD OF THE INVENTION
This invention relates to topical compositions for application to human skin and to their use in improving the condition and appearance of skin.
BACKGROUND AND PRIOR ART
Skin is subject to deterioration through dermatological disorders, environmental abuse (wind, air conditioning, central heating) or through the normal aging process (chronoaging) which may be accelerated by exposure of skin to sun (photoaging). In recent years the demand for cosmetic compositions and cosmetic methods for improving the appearance and condition of skin has grown enormously.
Consumers are increasingly seeking “anti-aging” cosmetic products which treat or delay the visible signs of chronoaging and photoaging skin such as wrinkles, lines, sagging, hyperpigmentation and age spots.
Consumers also frequently seek other benefits from cosmetic products in addition to anti-aging. The concept of “sensitive skin” has also raised the consumer demand for cosmetic products which improve the appearance and condition of sensitive, dry, rough and/or flaky skin and to soothe red, irritated and/or itchy skin. Consumers also desire cosmetic products which treat spots, pimples, blemishes etc.
Skin care cosmetic and dermatological compositions for improving the condition and appearance of skin comprising long chain triglyceride esters of polyunsaturated essential fatty acids, the free acids and their alkali or ammonium salts are well known in the art. For instance, GB 2181349 A describes inter alia a composition composed of triglycerides of linoleic acid for improving the smoothness and elasticity of skin. A commercial product, “Linola Fett n” ex Dr. August Wolff Gmbh, is available for the treatment of dry skin diseases, and dermatoses, which contains inter alia a mixture of the 9,11 isomers of conjugated linoleic acid.
There continues to be a need, however, for alternative effective cosmetic compositions for topical application to skin for treating/delaying the visible signs of aging and photodamaged skin such as wrinkles, lines, sagging, hyperpigmentation and age spots. Compositions and cosmetic methods which provide other skin care benefits in addition to anti-aging such as for improving the appearance and condition of dry, rough and flaky skin and to soothe irritated and itchy skin are particularly desirable.
We have now surprisingly found that effective treatment and prevention of normal skin conditions due to chronoaging or photoaging, such as wrinkles, lines, sagging, hyperpigmentation and age spots, and/or of sensitive, dry, rough, flaky, red, itchy, irritated skin may be obtained through the application of cosmetic compositions to the skin which are specifically enriched in a particular isomer of conjugated linoleic acid or derivatives thereof.
SUMMARY OF THE INVENTION
According to a first aspect of the present invention there is provided a topical composition comprising:
(a) conjugated linoleic acid, and/or derivatives thereof comprising conjugated linoleic acid moieties, in which at least 50% by weight of the conjugated linoleic acid and/or moieties is present as the cis 9 trans 11 isomer; and
(b) a dermatologically acceptable vehicle.
Such compositions are particularly useful for topical application to human skin for cosmetically treating/preventing skin conditions selected from the group consisting of wrinkling, sagging, photodamaged skin, sensitive skin, dry skin, rough skin, flaky skin, red skin, irritated skin, itchy skin and age spots. The compositions are also useful for application to the skin as a cosmetic treatment for spots, pimples and blemishes or as a cosmetic skin care product which promotes dermal repair and/or boosts collagen deposition in skin.
According to a second aspect the present invention provides a cosmetic method of treating/preventing skin conditions selected from the group consisting of wrinkling, sagging, photodamaged skin, sensitive skin, dry skin, rough skin, flaky skin, red skin, irritated skin, itchy skin and age spots, the method comprising applying to the skin a topical composition as described above.
In a further aspect, the invention also provides the use of conjugated linoleic acid, and/or derivatives thereof comprising conjugated linoleic acid moieties, in a topical composition for treating/preventing skin conditions selected from the group consisting of wrinkling, sagging, photodamaged skin, dry skin, rough skin, flaky skin, sensitive skin, irritated skin, itchy skin and age spots, wherein at least 50% by weight of the conjugated linoleic acid and/or moieties is present as the cis 9 trans 11 isomer.
The inventive compositions and methods thus provide anti-aging benefits which result in the promotion of smooth and supple skin with improved elasticity and a reduced or delayed appearance of wrinkles and aged skin with improved skin colour. A general improvement in the appearance, texture and condition, in particular with respect to the radiance, clarity, and general youthful appearance of skin is achieved. The inventive compositions and methods are also beneficial for soothing and calming sensitive, dry, rough, irritated, red, flaky and itchy skin. Thus the inventive methods and compositions advantageously provide a wide range of skin care benefits.
The term “treating” as used herein includes within its scope reducing, delaying and/or preventing the above mentioned skin conditions such as wrinkled, aged, photodamaged, dry and/or irritated skin and generally enhancing the quality of skin and improving its appearance and texture by preventing or reducing wrinkling and increasing flexibility, firmness, smoothness, suppleness and elasticity of the skin. The cosmetic compositions, methods and the uses of the conjugated linoleic acid according to the invention may be useful for treating skin which is already in a wrinkled, aged, photodamaged, dry and irritated condition or for treating youthful skin to prevent or reduce those aforementioned deteriorative changes due to the normal aging/photo aging process.
DETAILED DESCRIPTION OF THE INVENTION
Cis 9,trans 11 Isomer Enriched Conjugated Linoleic Acid
Conjugated linoleic acid (hereinafter referred to as CLA) comprises a group of positional and geometric isomers of linoleic acid in which various configurations of cis and trans double bonds at positions (6, 8), (7, 9), (8, 10), (9, 11), (10, 12) or (11, 13) are possible. Thus twenty-four different isomers of CLA exist.
The essential active of the compositions in accordance with the present invention is the c9, trans 11 (hereinafter referred to as c9, t11) isomer. This particular isomer of the free acid has the structure (I) shown below:
The invention also includes derivatives of the free acid which thus comprise conjugated linoleic acid moieties. Preferable derivatives include those derived from substitution of the carboxyl group of the acid, such as esters (eg retinyl esters, triglyceride esters, monoglyceride esters, diglyceride esters, phosphoesters), amides (eg ceramide derivatives), salts (eg alkali metal and alkali earth metal salts, ammonium salts); and/or those derived from substitution of the C18 carbon chain, such as alpha hydroxy and/or beta hydroxy derivatives.
In the case of triglyceride ester derivatives, all positional isomers of CLA substituents on the glycerol backbone are included. The triglycerides must contain at least one CLA moiety. For example, of the three esterifiable positions on the glycerol backbone, the 1 and 2 positions may be esterified with CLA and by another lipid at position 3 or as an alternative, the glycerol backbone could be esterified by CLA at the 1 and 3 positions with another lipid at position 2.
Wherever the term “conjugated linoleic acid” or “CLA” is used in this specification it is to be understood that the derivatives thereof comprising CLA moieties are also included. “CLA moieties” refers to CLA fatty acyl portion(s) of a CLA derivative.
By “c9 t11 isomer enriched CLA” is meant that at least 50% by weight of the total CLA (and/or CLA) moieties present in the composition is in the form of the cis 9, trans 11 is

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