Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2000-07-28
2002-07-23
Dees, Jose G. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C514S558000, C514S844000
Reexamination Certificate
active
06423325
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to topical compositions for application to human skin and to their use in improving the condition and appearance of skin.
BACKGROUND OF THE INVENTION
Skin is subject to deterioration through dermatological disorders, environmental abuse (wind, air conditioning, central heating) or through the normal ageing process (chronoageing) which may be accelerated by exposure of skin to sun (photoageing). In recent years the demand for cosmetic methods for improving the appearance and condition and, in particular, for reversing, reducing or preventing the visible signs of wrinkled, aged and/or photodamaged skin has grown enormously.
Consumers are increasingly seeking “anti-ageing” cosmetic products that reverse, treat or delay the visible signs of chronoaging and photoaging skin such as wrinkles, lines, sagging, hyperpigmentation and age spots.
Collagen, the predominant matrix skin protein is known to impart tensile strength to skin. It is also known in the art that the levels of collagen in skin are significantly reduced with aged and/or photodamaged skin. Many studies have shown that the levels of collagen type I in skin is decreased with age and/or with increased photodamage, (for example Lavker, R. J.Inv.Derm., (1979), 73, 79-66; Griffiths et al. N. Eng. J. med.(1993) 329, 530-535. The reduction of the levels of collagen in skin is accordingly associated with a decrease in the tensile strength of the skin causing wrinkles and laxity.
It is well known in the art that retinoic acid is a potent anti-ageing active and induces dermal repair of photodamaged skin. It has been shown that wrinkle effacement and dermal repair following topical treatment of skin with retinoic acid arises through new collagen deposition and synthesis in the skin (for example, Griffiths et al. N. Eng. J. med. (1993) 329, 530-535). It is widely accepted that strengthening of the dermal matrix by boosting the level of collagen in skin using retinoic acid provides anti-ageing/dermal repair benefits.
J05271046 describes a skin composition that contains an unsaturated fatty acid having 18 to 22 carbons and two or more unsaturated bonds, such as linoleic and arachidonic acid and a polyphenol. This composition is useful for lightening the skin.
Use of oils rich in petroselinic acid in skin care compositions as a moisturising agent has been described in EP A 0709084.
The use of fatty acids, including petroselinic acid, in cosmetic formulations for treating the hair is known. EP-A-116439 describes hair tonics, which include fatty acids, such as petroselinic acid, linoleic acid, linolenic acid oleic acid and arachidonic acid for alleviating dandruff and for stimulating hair growth.
We have now found that effective treatment and prevention of normal, but cosmetically undesirable, skin conditions, due to chronoaging or photoaging, such as wrinkles, lines, sagging, hyperpigmentation and age spots, may be obtained through the application of cosmetic compositions to the skin which comprises a specific combination of two lipid components.
The art discussed above does not disclose the specific synergistic combination of a first lipid component selected from petroselinic acid or docosahexaenoic acid together with a second lipid component, nor the use of such a specific combination for treating ageing skin.
SUMMARY OF THE INVENTION
According to a first aspect of the present invention there is provided a topical composition comprising:
(a) a first lipid component selected from petroselinic acid and/or docosahexaenoic acid and/or derivatives thereof;
(b) a second lipid component which is an activator of peroxisome proliferator activated receptors of sub-type alpha and/or derivatives thereof and/or mixtures thereof; and
(c) a dermatologically acceptable vehicle.
According to a second aspect of the present invention there is provided a cosmetic method of providing at least one skin care benefit selected from: treating/preventing wrinkling, sagging, dry, aged and/or photodamaged skin; boosting collagen deposition in skin, boosting decorin production in skin, enhancing tissue repair; improving skin texture, smoothness and/or firmness; the method comprising applying to the skin a topical composition as described above.
The present invention also encompasses the use of the inventive compositions for providing at least one skin care benefit selected from treating/preventing wrinkling, sagging, aged and/or photodamaged skin; boosting collagen deposition in skin, boosting decorin production in skin, enhancing tissue repair; and improving skin texture, smoothness and/or firmness.
According to a still further aspect of the present invention there is provided the use of a first lipid component selected from petroselinic acid and/or docosahexaenoic acid and/or derivatives thereof in combination with a second lipid component which is an activator of the peroxisome proleferator activated receptor sub-type alpha and/or derivatives thereof and/or mixtures thereof in a cosmetic topical composition for providing at least one cosmetic skin care benefit selected from treating/preventing wrinkling, sagging, aged and/or photodamaged skin; boosting collagen deposition in skin, boosting decorin production in skin, enhancing tissue repair; and improving skin texture, smoothness and/or firmness.
The inventive compositions, methods and uses thus provide anti-ageing benefits which result in the promotion of smooth and supple skin with improved elasticity and a reduced or delayed appearance of wrinkles and aged skin, with improved skin colour. A general improvement in the appearance, texture and condition, in particular with respect to the radiance, clarity, and general youthful appearance of skin is achieved.
The term “treating” as used herein includes within its scope reducing, delaying and/or preventing the above mentioned normal, but cosmetically undesirable, skin conditions caused by the normal ageing process. The visible signs of aging, such as wrinkles, lines and/or sagging are delayed or reduced. Generally, the quality of skin is enhanced and its appearance and texture is improved by preventing or reducing wrinkling and increasing flexibility, firmness, smoothness, suppleness and elasticity of the skin. The compositions, methods and uses according to the invention may be useful for treating skin that is already in a wrinkled, aged, and/or photodamaged condition or for treating youthful skin to prevent or reduce those aforementioned undesirable changes due to the normal ageing/photoageing process.
DETAILED DESCRIPTION OF THE INVENTION
Petroselinic Acid and Docosahexaenoic Acid
Petroselinic acid (hereinafter referred to as PA) is a monounsaturated long chain (C18) fatty acid, having the formula CH
3
(CH
2
)
10
CH═CH(CH
2
)
4
COOH.
Docosahexaenoic acid (hereinafter referred to as DHA) is a polyunsaturated long chain (C
22
) fatty acid having the formula CH
3
(CH
2
CH═CH)
6
CH
2
CH
2
COOH.
The invention also includes derivatives of the free acid which thus comprise petroselinic acid/docosahexaenoic acid moieties. Preferable derivatives include those derived from substitution of the carboxyl group of the acid, such as esters (e.g. triglyceride esters, monoglyceride esters, diglyceride esters, phosphoesters), amides (e.g. ceramide derivatives), salts (e.g. alkali metal and alkali earth metal salts, ammonium salts); and/or those derived from substitution of the C18/C
22
carbon chain, such as alpha hydroxy and/or beta hydroxy derivatives.
In the case of triglyceride ester derivatives, all positional isomers of PA/DHA substituents on the glycerol backbone are included. The triglycerides must contain at least one PA/DHA moiety. For example, of the three esterifiable positions on the glycerol backbone, the 1 and 2 positions may be esterified with PA/DHA and by another lipid at position 3 or as an alternative, the glycerol backbone could be esterified by PA/DHA at the 1 and 3 positions with another lipid at position 2.
Oils that are rich in petroselinic acid triglyceride are thus also suitable for use in the p
Alaluf Simon
Rawlings Anthony Vincent
Conopco Inc.
Dees Jos,e G.
Lamm Marina
Plotkin Ellen
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