Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Silicon dioxide containing
Patent
1998-07-07
2000-07-11
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Silicon dioxide containing
A61K 3300
Patent
active
060869240
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a method and composition, notably to a method for the treatment of acne and a composition for topical application in such a method.
BACKGROUND TO THE INVENTION
Many people suffer from acne and related skin disorders in which the sebaceous glands secrete excessive amounts of oily material and cause localised accumulations of oils in the surface layers of the skin, giving rise to unsightly red spots or areas of skin. In extreme cases, these spots can become infected and cause damage to the skin. For convenience, the term acne will be used herein to denote skin disorders which result from secretions of sebum in the skin whose symptoms include skin rashes and inflammations as well as spots and pimples.
There have been many attempts to provide successful treatment for acne, and many of these have been based upon anti-biotic formulations. However, these are expensive and do not provide immediate and effective treatment.
I have now found that fine particulate silica, notably colloidal or precipitated silica or partial hydrates thereof, is remarkably effective in providing rapid alleviation of the symptoms of acne and related skin disorders, that is the spots, inflammation and red areas of the skin caused by the underlying disorder.
SUMMARY OF THE INVENTION
Accordingly, the present invention provides a method for the alleviation of the symptoms of acne and related skin disorders in mammals, which method comprises applying to the affected area of the skin of the mammal a non-aqueous composition comprising a dermatologically effective amount of a particulate silica, which may be an anhydrous form or a partial hydrate thereof or precursor thereof.
The invention also provides a dermatologically active composition for topical application to the skin of a mammal suffering from acne, which composition comprises a dermatologically effective amount of a particulate silica, which may be an anhydrous form or a partial hydrate thereof or precursor thereof, in an non-aqueous carrier medium.
For convenience the term silica will be used herein to denote silica itself, that is SiO.sub.2 ; partial hydrates of silica, for example those of the formula Si[SiO].sub.2-4 [OH].sub.1-2 ; those amorphous materials known as precipitated silica, colloidal silicon dioxide and fumed silica; silicic acid; or silica gel. A particularly preferred form of silica for present use is that fumed silica sold by Degussa AG under the trade mark Aerosil.
The silica for present use may also be used in the form of a precursor thereof, for example a higher hydrate of silica which readily loses water of hydration due to the heat generated during milling to reduce the particle size of the initial material to the desired small particle size so as to form the desired lower hydrate in situ. The term silica is therefore used herein wherever the context permits to include other compounds of silicon, notably the organic derivatives of silicon and the higher hydrates of silica, which form the desired form of silica in situ during the processing of the ingredients to form the compositions of the invention.
For convenience, the invention will be described hereinafter in terms of the use of fine particle size silica.
I believe that the compositions of the invention act by way of removal of fluid from the affected area of the skin causing the fluid secretion in the skin to migrate to the topically applied composition where it absorbed or adsorbed by the silica deposited on the skin from the compositions of the invention. That silica itself should be effective in the treatment of acne and related disorders is highly unexpected in view of the known inert nature of silica. I believe that, in the case of some forms of the silica, the fluid is absorbed by the silica as water of hydration and/or combination, for example in the case of silica gel. However, in other cases, the fluid is adsorbed within the inter-particle interstices of the deposit of silica particles on the skin due to capillary action. This latter mechanism has never been p
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STN, File Supplier, Karlsruhe, DE, File XP002030245, Chemical Abstracts, vol.107, AN=102684.
Hochberg D. Peter
Holt William H.
Jarvis William R. A.
Kim Vickie
Stiefel Laboratories (Ireland) Limited
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