Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2000-01-10
2001-06-19
Dodson, Shelly A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S059000, C424S060000, C424S074000, C424S070900, C424S195110, C424S600000, C424S661000, C424S677000, C424S723000, C514S844000, C514S859000, C514S861000, C514S863000
Reexamination Certificate
active
06248340
ABSTRACT:
FIELD OF THE INVENTION
The present invention generally relates to a composition useful for care of skin conditions and for skin protection and to a method for its preparation. The present invention further relates to a method for skin care and protection using said composition. More specifically, the present invention relates to a composition combining plant and algae extracts with water solutions from the Dead Sea especially useful for treating skin wrinkles and retaining skin moisture, to a method for the preparation thereof and to a method for skin care and protection comprising dermal application of said composition.
BACKGROUND OF THE INVENTION
The skin is the largest organ in the body and serves as a protective barrier from the external environment, impeding the entry of microorganisms, absorption of radiation and loss of water. The skin is composed of three layers differing in their cell types and special functions; an overlaying epithelial layer (epidermis), an underlying connective tissue matrix (dermis) and adipose tissue (hypodermis). Skin roughness is one of the main criteria for assessing the health status of human skin. Changes in ski surface roughness, which give the skin the effect of having wrinkles, may occur due to congenital keratinization disturbances, environmental and job related skin irritations, infectious skin diseases and age related defects. Some skin disorders are related to a specific mineral shortage. About 4-5% of the human body is made up of minerals. It is assumed that specific ions from minerals play an important role in healthy skin metabolism. There are indications that Mg
+2
is a co factor for phosphate transferring enzymes and participates in cAMP regulation. Ca
+2
is thought to induce lamellar body secretion and regulate cell membrane permeability and K
+
is known to enhance CO
2
transport. In some in vitro and in vivo tests magnesium bromide, magnesium chloride, and potassium bromide (all selected Dead Sea salts) exhibited inhibition of skin cell proliferation after dermal application, making them possibly applicable for care of psoriasis (As discussed by Shani, J., Sulliman, A., Katzir, I, and Brener, S. in J. Eur. Acad. Dermratol. Venereol. (1995) 4, 267-272 and by Levi-Shaffer, F., Shani, J., Politi, Y., Rubinichik, E. and Brener, S. in Pharmacology (1996) 52, 321-328). Minerals are capable of restoring moisture due to their hygroscopic characteristics. Minerals, if absorbed into skin cells, may enhance intracellular water capacity. Minerals may be absorbed into the skin from brine, from a bath with dissolved salts, or from application of a mineral rich preparation.
The Dead Sea is the richest natural mineral source in the world, with a concentration of 32% (w/v) dissolved minerals and a unique composition. The main elements found in Dead Sea water are chlorine, magnesium, sodium, calcium, potassium and bromine. For example, the concentration of chlorine in the Dead Sea is 224900 mg/l as opposed to 22900 in the Mediterranean and 19000 in typical ocean water. Magnesium is 44000 mg/l in the Dead Sea as opposed to 1490 and 1350 in the Mediterranean and ocean, respectively. Sodium is 40100 mg/l in the Dead Sea as opposed to 12700 and 10500 in the Mediterranean and ocean, respectively. Calcium is 17200 mg/l in the Dead Sea as opposed to 470 and 400 in the Mediterranean and ocean, respectively. Potassium is 7650 mg/l in the Dead Sea as opposed to 470 and 390 in the Mediterranean and ocean, respectively and bromine is 5300 mg/l in the Dead Sea as opposed to 76 and 65 in the Mediterranean and ocean, respectively.
It has been acknowledged for years that these elements are beneficial for human skin and health. Minerals are alleged to relieve diseases such as rheumatism, acne, eczema and psoriasis (Ma'or, Z., Magdassi, S., Effron, D., Yehuda, S
Isr. J. Med. Sci.
32 (suppl 3), 28-35 (1996)). Algae and plants are an especially rich natural source of vitamins and minerals. Algae grown in mineral rich water and in severe environmental conditions are capable of concentrating large amounts of these substances. Uses for algae in food and in external dermal applications, are known, and the use of marine algae in spas is prevalent. There is a large world market for cosmetic compositions containing minerals. However, the benefits of minerals in Dead Sea water are limited due to the natural high concentration of divalent ions and the very high ionic strength of the Dead Sea water. Another drawback of the mineral rich cosmetics marketed today is the fact that the skin itself presents a natural barrier to the penetration of minerals. These drawbacks have a negative effect on the formation and stability of compositions.
The present invention relates to a composition for skin care, especially for care of changes in skin surface roughness (wrinkles), for retaining skin moisture and for relieving skin related diseases such as acne, eczema and psoriasis. The composition of the present invention combines Dead Sea water solutions with algae and plant extracts, achieving a highly mineral rich composition and utilizing the algae bio mass as a carrier of minerals and their possibly controlled release, thereby overcoming the drawbacks of the compositions marketed today and presenting a superior composition for cosmetic use and skin care and protection.
DETAILED DESCRIPTION OF THE INVENTION
The present invention relates to a composition for care of skin conditions, especially changes in skin surface roughness (wrinkles), for retaining skin moisture, and for care of skin related diseases. Skin roughness is one of the main criteria for assessing the health status of human skin. Changes in skin surface roughness, which give the skin the effect of having wrinkles, may occur due to congenital keratinization disturbances, environmental and job related skin irritations (toxic and allergic eczema), infectious skin diseases, UVA and UVB radiation induced skin damages and age related defects. Some skin disorders are related to a specific mineral shortage. About 4-5% of the human body is made up of minerals. It is assumed that specific ions from minerals play an important role in healthy skin metabolism. The composition of the present invention combines Dead Sea water solutions with algae and plant extracts, achieving a highly mineral rich composition, useful for care of skin conditions and for skin protection. Preparation of the composition of the present invention is preferably a two stage process wherein the first step is the preparation of a base comprising:
hydrosoluble (HS) Dunaliella extract
11-11.8%
w/w
Trigonella foenum extract HS
4.5-4.7%
w/w
Zizyphus extract HS
16.7-17.6%
w/w
Sclerotium Gum
0.5-0.6%
w/w
Methylparaben
0.075-0.08%
w/w
Propylparaben
0.0375-0.04%
w/w
Water
to add up to 100%
w/w
This base is a yellow-orange liquid with the typical characteristics of a pH of about 4.5-6.5, a density (at 20° C.) of about 1.03-1.04, a refractive index (at 20° C.) of about 1.370-1.380 and a water percentage of about 65%. A microbiological analysis showed there to be no aerobic germs or yeasts or molds. The second step is the adding of 10-15% Dead Sea water resulting in the composition of the present invention comprising:
hydrosoluble (HS) Dunaliella extract
10%
w/w
Trigonella foenum HS extract
4%
w/w
Zizyphus HS extract
15%
w/w
Dead Sea Water
10-15%
w/w
Sclerotium Gum
0.5%
w/w
Methylparaben
0.07%
w/w
Propylparaben
0.035%
w/w
Water
to add up to 100%
w/w
This composition is a yellow-orange liquid with the typical characteristics of a pH between 4.5 to 6.5, a density (at 20° C.) of about 1.00-1.11, a refractive index (at 20° C.) of about 1.39-1.40 and a water percentage of about 64%. A microbiological analysis showed there to be less than 100/g aerobic germs and no yeasts or molds. Dead Sea Water, as defined in the present invention, comprises a clear colorless viscous liquid (at 25° C.) with a specific density of 1.3-1.34 g/ml, pH=4.7-5.3 (at 25° C.), loss on drying (at 120° C.) of 49-50%/w and less than 100 cfu/gr and non pathogenic microbes. The
Maor Zeev
Yehuda Shaul
Dead Sea Laboratories Ltd.
Dodson Shelly A.
Lamm Marina
Mayer Brown & Platt
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