Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Reexamination Certificate
1999-09-21
2001-11-13
Hartley, Michael G. (Department: 1619)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
Reexamination Certificate
active
06315980
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a skin barrier function recovery and promotion composition and an evaluation method thereof and more specifically relates to an improvement in the effective ingredient.
2. Description of the Related Art
In recent years, the aromatherapy has been interested as a method for the treatment capable of being easily used and having relatively few side-effects. In particular, it has been noted as an effective method for the treatment of unidentified climical syndrome, autonomic imbalance, and other psychosomatic disorders due to cause of stress. There are various fragrances known as aromatherapy agents for alleviation of various symptoms. Among these, there are fragrances which are considered effective for improvement of the skin.
However, the effects thereof are vague due to the judgement of experience to a large extent. There are few fragrances which are known to possess clear specific pharmacological effects. Especially, they have not been offered as medicines or agents particularly effective for recovery or promotion of the skin barrier function.
Further, while research on the physiological action of fragrances has been relatively often carried out, there has been little research on the improvement of the skin functions by inhalation of the scent of fragrances and there has not been any objective method for evaluation of the effectiveness thereof either. Therefore, it has been difficult to find fragrances effective as agents for the recovery or promotion of the skin barrier function.
SUMMARY OF THE INVENTION
Accordingly, the objects of the present invention are to eliminate the above-mentioned problems of the prior art and to provide A skin barrier function recovery and promotion composition containing a fragrance and a simple method for evaluating the effectiveness thereof.
In accordance with the present invention, there is provided a skin barrier function recovery and promotion composition comprising (i) at least 0.01% by weight, based upon the total weight of the composition, of at least one skin barrier function recovery and promotion agent selected from the group consisting of terpinyl acetate, phenethyl alcohol, and dimethoxymethylbenzene and (ii) a cosmetically or pharmacologically acceptable carrier thereof.
In accordance with the present invention, there is also provided a skin barrier function recovery and promotion composition comprising (i) at least 0.01% by weight, based upon the total weight of the composition, of at least one skin barrier function recovery and promotion agent selected from the group valerian fragrance, violet fragrance and a rose fragrance and (ii) a cosmetically acceptable carrier thereof.
In accordance with the present invention, there is further provided a method for evaluating the effectiveness of the capability of a test fragrance to recover a skin barrier function comprising:
applying a predetermined stress to a model experimental animal, in a system to which the fragrance is not applied, to thereby reduce the skin barrier function of the animal
determining the degree of recovery of the reduced skin barrier function, of which data is used as an indicator for evaluation and
determining the data of the degree of recovery of the skin barrier function in a system to which the fragrance is applied, and
evaluating the effectiveness from the difference of the data between the degrees of the recovery of the skin barrier functions in the two systems.
REFERENCES:
patent: 5204099 (1993-04-01), Barbier et al.
patent: 1-254628 (1989-10-01), None
Pare et al., “Restraint Stress in Biomedical Research: A Review,”Neuroscience&Biobehavioral Reviews, vol. 10, pp. 339-370, (1986).
Denda Mitsuhiro
Shoji Ken
Tanida Masahiro
Tsuchiya Toru
Foley & Lardner
Hartley Michael G.
Shiseido Company Ltd.
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