Skin application agents

Details Skin application agents Skin application agents

2000-09-20

2002-10-29

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

C042S130000, C042S130000, C042S130000, C042S130000, C042S130000, C514S772400

Reexamination Certificate

active

06471983

ABSTRACT:

The present invention relates to a skin application agent containing a polyisoprene latex.
Skin application agents, e.g. face masks, plasters and washing pastes, which often contain polymer latices, have been well-known for many years. However, the frequent disadvantage of these skin application agents is that they irritate the skin and are not toxicologically safe.
WO 00/17300 teaches a skin cleansing agent, which consists of a latex emulsion, an organosilicone compound, emollients, surface-active agents and water. The latex emulsion preferably has a styrene-butadiene copolymer.
The disadvantage of the above-mentioned skin cleansing agents is that they only have limited skin compatibility, are not toxicologically safe and/or pose environmental risks.
Well-known from EP 0,535,789 A2 is a cleansing composition for tropical applications, which contains a mixture of a surface-active agent, an emollient, a cationic material, a film former, a polyaminosugar condensate and water.
The object is therefore to provide a skin application agent which is toxicologically safe and causes similar or less skin irritation compared to the skin application agents of the prior art.
According to the invention, said object is accomplished by a skin application agent which contains a polyisoprene latex.
According to the invention, the skin application agent has a polyisoprene latex. This polyisoprene latex preferably has a content of at least 90% by weight cis-1,4-isoprene. The size of the polyisoprene particles in the latex is equally preferably 1.8 &mgr;m maximum. Furthermore, the latex has a solids content of preferably 20 to 90% by weight and especially preferably 60 to 80% by weight.
In a preferred embodiment, the skin application agent is a cosmetic and/or medical skin application agent of any kind. The medical skin application agent in particular preferably has at least one transdermal active ingredient.
The skin application agent is preferably a skin cleansing agent, preferably a washing paste and particularly a hand washing paste. These skin cleansing agents can contain organic solvents in addition to the polyisoprene latex.
The solvent preferably has a lower volatility than ethanol and a boiling point >78.32° C., the boiling point being measured at a pressure of 1.013 bar. The solvent preferably is at least one
polyhydric alcohol or derivative of a polyhydric alcohol, particularly a polydiol, preferably an alkylene glycol, a polyalkylene glycol, a polydiol derivative, and preferably a polyalkylene glycol ether and/or polyalkylene glycol ester,
mono- or polyester of a saturated or unsaturated mono- or polyvalent carboxylic acid with 2 to 30 carbon atoms with n- and isoalkanols with 2 to 10 carbon atoms, preferably a diester of aliphatic and/or aromatic di- and/or tricarboxylic acids, and/or
aliphatic hydrocarbon with 12 to 22 carbon atoms, preferably with 16 to 20 carbon atoms and particularly preferably isohexadecane,
or a mixture of at least two of the above-mentioned substances.
Preferred polyalkylene glycols or their esters or ethers are listed in the tables from Ullmann, 4th edition, volume 8, pages 200, 204, 205, 207 and volume 19, pages 426 and 428.
These tables are hereby incorporated by reference and are thus deemed part of the disclosure.
Particularly preferred is the solvent dipropylene glycol monomethyl ether.
The ratio of polyisoprene latex to solvent is preferably 8:1 to 1:1, and more preferably 4:1 to 2:1.
The skin cleansing agent may optionally contain a surfactant. This surfactant is preferably a fatty alcohol ethoxylate of general formula: R—O—(CH
2
—CH
2
—O)
n
with R=C
8-18
and n=1-8, preferably R=C
12-14
and n=4-6. The surfactant is also preferably a fatty alcohol ether sulfate of general formula: R—O—(CH
2
—CH
2
—O)
n
SO
4
X
2
with R=C
10-16
and n=1-4 and X=Na
+
, K
+
, ½ Mg
2+
or NH
4
+
.
The skin cleansing agent preferably contains at least one abrasive. The abrasives can be conventional abrasives or mixtures thereof, and preferably bleached walnut shell meal, non-swellable starch or a mixture thereof.
To modify the consistency of the skin cleansing agent, the latter can also contain water-swellable polymers as thickeners, whereby polymers obtainable from the polymerization of acrylic acid and xanthan gum are preferably employed.
The skin cleansing agent may contain cosmetic adjuvants and/or additives and/or active ingredients, e.g. care derivatives, emollients, perfume (fragrances), preservatives etc..
In a preferred embodiment, the skin cleansing agent contains:
a) 10-80% by weight of a liquid natural and/or synthetic water-based polyisoprene latex emulsion,
b) 1-15% by weight of an organic solvent having a lower volatility than ethanol and a boiling point >78.32° C.,
c) 0-10% by weight of at least one surfactant, preferably at least one fatty alcohol ethoxylate, fatty alcohol ether sulphate, succinate, sarcoside and/or glucoside,
d) 0-10% by weight of abrasives, preferably bleached walnut shell meal and/or non-swellable starch,
e) 0-1% by weight thickener,
f) optionally cosmetic adjuvants and additives and/or active ingredients,
g) 10-60% by weight water,
to make a total of 100% by weight.
In another preferred embodiment, the skin application agent is a face mask which preferably contains 60-80% by weight polyisoprene and 20-40% by weight water and possibly 0-20% by weight additives, the total always yielding 100% by weight.
The additives are preferably cleansing and/or care components. Examples of cleansing components are ionic and nonionic surfactants, preferably wheat germ hydrolyzates, betaines, sarcosides and/or sulfosuccinates.
Preferably employed as the care components are at least one vitamin, at least one herb or at least one component of a herb, at least one herbal mixture, e.g. bisabolol, azulene, at least one fruit powder and/or at least one component of a fruit, particularly a vitamin, a fruit powder and, for instance, bisabolol, azulene and/or panthenol-2 and/or tanning components, e.g. hamamelis.
In another preferred embodiment of the present invention, the skin application agent is a plaster, and particularly a spray plaster.
The advantage of the skin application agent according to the invention is that it is toxicologically safe and less harmful to the environment and irritates the skin at least no more than products of the prior art.
The present invention is also directed to a method for the medical and/or cosmetic treatment of the skin, characterized in that a skin application agent according to the invention is applied to the skin, left there for a certain period and removed subsequently or immediately after application, being preferably rubbed off and/or washed off.
The time for which the skin application agent according to the invention is left on the skin depends on the agent's purpose. For a hand washing paste the period is 1 to 2 minutes, for a face mask 10 to 30 minutes, and for a plaster several days. The person skilled in the art realizes that, in the case of a plaster and particularly a spray plaster, the skin application agent according to the invention can also be removed together with the slough.
The advantage of the method according to the invention is that it is toxicologically safe and less harmful to the environment.
The invention will be explained below with reference to the Examples. These explanations merely exemplify and do not limit the general idea of the invention.
A. Hand Washing Pastes
Test Methods
1. Skin Compatibility, Using the Duhring Chamber Test
This method is an in vivo test model for examining the skin compatibility of various test products in a direct comparison. The products being tested are applied in air-permeable aluminum chambers (18 mm diameter Finn Chambers®) each time to the same test area on the volar side of the lower arms of 20 test subjects on four successive days. The application times are two hours on the first, four hours on the second and six hours on the third and fourth days respectively. The Finn Chamb

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