Skin adhesive hydrogel, its preparation and uses

Details Skin adhesive hydrogel, its preparation and uses Skin adhesive hydrogel, its preparation and uses

1992-12-09

1994-04-26

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424401, 424443, 424445, 424448, 424486, 424487, 514781, 514789, 514946, 604307, 602 48, A61F 1300

Patent

active

053065042

ABSTRACT:
A skin adhesive hydrogel formed by mixing in aqueous medium: (A) major proportion of a high molecular weight water-soluble polyvinylpyrrolidone having ring opened pyrrolidone groups and (B) a minor proportion of a water-soluble multifunctional amine-containing polymer to form a water insoluble, water swellable cross-linked salt between carboxyl groups of the ring opened pyrrolidone groups and basic amine groups of the polyfunctional amine-containing polymer. The reaction is advantageously carried out in the presence of a plasticizer.

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H. P. Frank, "The Lactam-Amino Acid Equilibra for Ethylpyrrolidone and Polyvinypyrrolidone", J. Poly Sci, 12, 565-576 (1954).
A. Conix and G. Smets, "Ring Opening in Lactam Polymers", Journal of Polymer Science, XV, 221-229 (1955).

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