Size-selective hemoperfusion polymeric adsorbents

Details Size-selective hemoperfusion polymeric adsorbents Size-selective hemoperfusion polymeric adsorbents

2011-01-25

2011-01-25

Eashoo, Mark (Department: 1796)

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

C424S529000, C424S634000, C424S644000, C521S050000, C521S061000, C521S076000, C521S134000, C521S142000, C530S415000

Reexamination Certificate

active

07875182

ABSTRACT:
Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (Å) in diameter with a working pore size range within 100 to 300 Å in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and β2-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.

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