Six membered ring fused imidazoles substituted with phenoxypheny

Details Six membered ring fused imidazoles substituted with phenoxypheny Six membered ring fused imidazoles substituted with phenoxypheny

1993-03-19

1994-12-20

Cinthins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514319, 514323, 514327, 514381, 514826, 514405, 514410, 514413, 514303, A61K 31445, A61K 3141

Patent

active

053746384

ABSTRACT:
Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

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K. Noguchi, et al., European Journal of Pharmacology 233, pp. 47-51 (1993).
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T. Masaki, et al., Medicinal Research Reviews, 12, No. 4, pp. 391-421 (1992).
Burger; Medicinal Chemistry, published by Wiley-Interscience, New York, N.Y.-(1971) p. 77.
07/744,557, 08001991, Greenlee, W. J. et al.

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