Six-membered ring fused imidazoles substituted with phenoxypheny

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 81, 514256, 5142342, 544127, 544333, 546 23, 546118, A61K 31435, C07D47104

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active

053345983

ABSTRACT:
Phenoxyphenylacetic acids and derivatives of general structural formula I have endothelin ##STR1## antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

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patent: 5114918 (1992-05-01), Ishikawa et al.
patent: 5177095 (1993-01-01), Greenlee et al.
patent: 5183810 (1993-02-01), Greenlee et al.
patent: 5187195 (1993-02-01), Oohata et al.

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