Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Reexamination Certificate
2006-12-27
2010-02-16
Jiang, Dong (Department: 1646)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
C530S387100, C530S387300, C530S388100, C530S388220, C530S389100, C530S350000, C530S387900
Reexamination Certificate
active
07662376
ABSTRACT:
The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, SSG. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the activity of SSG.
REFERENCES:
patent: 7033810 (2006-04-01), Tian et al.
patent: 7138493 (2006-11-01), Dean et al.
patent: WO 00/58473 (2000-10-01), None
Senent, et al, 1998, Haematologica, 83: 783-787.
Sparrow, et al, 2002, A Potent Synthetic LXR Agonist Is More Effective than Cholesterol Loading at Inducing ABCA1 mRNA and Stimulating Cholesterol Efflux, J. Biol. Chem., 277(12): 10021-10027.
Stefkova et al., “ATP—Binding Cassette (ABC) Transporters in Human Metobolism and Diseases,” Physiological Research, 53(3):235-243 (2004).
Attwood et al., “Which craft is best in bioinformatics?” Comput. Chem. 2001, 54(4), pp. 329-339 (2001).
Croop, “Evolutionary Relationships among ABC Transporters,” Meth. Enzym., 292:101-165 (1998).
Higgins, “ABC Transporters: From Microorganisms to Man,” Ann. Rev. Cell. Biol., 8:67-113 (1992).
Hobbs etal., “ABC1: connecting yellow tonsils, neuropathy, and very low HDL,”J. Clin. Invest., 104(8):1015-1017 (1999).
Klucken et al., “AGCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport,” PNAS, 97(2):817-822 (2000).
Lawn et al., “The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway,” J. Clin. Invest., 104(8):R25-R31 (1999).
Lee et al., “Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption,” Nature Genetics, 27(1):79-83 (2001).
Lee et al., “Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption,” Abstract, AC No. AF312713, Jan. 24, 2001.
Lee et al., “Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption,” Abstract, AC No. AF312715, Jan. 24, 2001.
Lehmann et al., “Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway,” J. Biol. Chem., 272(6):3137-3140 (1997).
Marra et al., “The WashU-HHMI Mouse EST Project,” Abstract, AC No. AA244605, Mar. 11, 1997.
Marra et al., “The WashU-HHMI Mouse EST Project,” Abstract, AC No. AA239884, Mar. 6, 1997.
Patel et al., “Mapping a Gene Involved in Regulating Dietary Cholesterol Absorption,” J. Clin. Invest., 102(5):1041-1044 (1998).
Sulston et al., “Toward a complete human genone sequence,” Abstract, ID No. AC011242, Genome Research, 8(11):1097-1108 (1998).
Tzermia et al., “Sequence analysis of a 33.2 kb segment from the left arm of yeast chromosome XV reveals eight known genes and ten new open reading frames including homologues of ABC transporters, inositol phosphatases and human expressed sequence tags,” Abstract, AC No. Q08234, Q08233, Oct. 16, 2001.
Willy et al., “LXR, a nuclear receptor that defines a distinct retinoid response pathway,” Genes Dev., 9:1033-45 (1995).
Schultz Joshua
Shan Bei
Tian Hui
Amgen Inc.
Ausenhus Scott L.
Jiang Dong
Wegert Sandra
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