Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2004-10-29
2008-11-11
Lankford, L B (Department: 1651)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C530S407000, C525S054100, C514S002600, C514S012200, C435S007500
Reexamination Certificate
active
07449558
ABSTRACT:
An in vivo method for labelling a protein having an N-terminal cysteine is disclosed. A probe comprising a thioester group and a detectable label is introduced into a cell expressing the N-terminal cysteine protein, allowing for the N-terminal cysteine to cleave the thioester bond and resulting in the label being covalently attached to the N-terminus of the protein by an amide bond.
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Yao Shao Qin
Yeo Su-Yin Dawn
Kim Taeyoon
Klarquist & Sparkman, LLP
Lankford L B
National University of Singapore
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